Susceptibility of the aging lung to environmental injury.

Susceptibility of the aging lung to environmental injury.
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DOI:
10.1055/s-0030-1265895
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发表时间:
2010-10
影响因子:
3.2
通讯作者:
Pinkerton KE
Pinkerton KE
中科院分区:
医学3区
文献类型:
--
作者:
Wang L;Green FH;Smiley-Jewell SM;Pinkerton KE

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随着世界上老年人数量的不断增加,需要更好地了解与老龄化和环境相关的问题。呼吸系统是人体与外界环境的主要接口之一。越来越多的研究表明,老化的肺部系统(>65岁)因环境污染(如空气污染物,感染和气候变化)而对健康产生不利影响的风险增加。然而,该亚群中易感性增加的机制尚不清楚。在这篇综述中,我们提供了一个有限的,但全面的概述如何肺的年龄,环境暴露的例子与损伤老化的肺和潜在的机制,强调增加的脆弱性老化的肺损伤的环境因素。
With an ever increasing number of elderly individuals in the world, a better understanding of the issues associated with aging and the environment is needed. The respiratory system is one of the primary interfaces between the body and the external environment. An expanding number of studies suggest that the aging pulmonary system (>65 years) is at increased risk for adverse health effects from environmental insult, such as by air pollutants, infection, and climate change. However, the mechanism(s) for increased susceptibility in this subpopulation is not well understood. In this review, we provide a limited, but comprehensive overview of how the lung ages, examples of environmental exposures associated with injury to the aging lung and potential mechanisms underlining the increased vulnerability of the aging lung to injury from environmental factors.
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