Susceptibility of the aging lung to environmental injury.
Susceptibility of the aging lung to environmental injury.
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DOI:
10.1055/s-0030-1265895
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发表时间:
2010-10
影响因子:
3.2
通讯作者:
Pinkerton KE
中科院分区:
文献类型:
--
作者:
Wang L;Green FH;Smiley-Jewell SM;Pinkerton KE
With an ever increasing number of elderly individuals in the world, a better understanding of the issues associated with aging and the environment is needed. The respiratory system is one of the primary interfaces between the body and the external environment. An expanding number of studies suggest that the aging pulmonary system (>65 years) is at increased risk for adverse health effects from environmental insult, such as by air pollutants, infection, and climate change. However, the mechanism(s) for increased susceptibility in this subpopulation is not well understood. In this review, we provide a limited, but comprehensive overview of how the lung ages, examples of environmental exposures associated with injury to the aging lung and potential mechanisms underlining the increased vulnerability of the aging lung to injury from environmental factors.
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