High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer.
High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer.
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DOI：
10.1038/bjc.2011.46
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发表时间：
2011-03-15
影响因子：
8.8
通讯作者：
Salvesen, H. B.
中科院分区：
文献类型：
--
作者：
Mauland, K. K.;Trovik, J.;Wik, E.;Raeder, M. B.;Njolstad, T. S.;Stefansson, I. M.;Oyan, A. M.;Kalland, K. H.;Bjorge, T.;Akslen, L. A.;Salvesen, H. B.
子宫内膜癌的发病率在工业化国家正在增加。高体重指数（BMI，kg m−2）与疾病风险较高相关。我们想研究BMI是否与子宫内膜癌的临床病理特征、原发肿瘤的激素受体状态和疾病结局有关。总共有1129名妇女在1981-2009年期间在Haukeland大学医院接受了子宫内膜癌的初步治疗。949例患者的体重指数与综合临床和组织病理学数据、肿瘤激素受体状态、治疗和随访相关。高BMI与国际妇产科联合会（FIGO）分期低、类腺瘤组织学、低/中级和高水平孕激素受体（PR）mRNA（qPCR法n=150; P=0.02）和蛋白表达（免疫组化法n=433; P=0.003）显著相关。相反，雌激素受体（ERα）状态与BMI无关。在单变量分析中，超重/肥胖妇女的疾病特异性生存率（DSS）显著高于正常/体重不足妇女（P=0.035）。在调整年龄、FIGO分期、组织学亚型和分级的DSS多变量分析中，BMI没有显示出独立的预后影响。在一项基于大量人群的子宫内膜癌研究中，高BMI与非侵袭性疾病标志物和PR阳性状态显著相关。在DSS的单变量分析中，高BMI的妇女有明显更好的预后，在多变量分析中，这种影响消失了，调整了既定的预后指标。PR在子宫内膜癌发生中的作用有待进一步研究。
Endometrial cancer incidence is increasing in industrialised countries. High body mass index (BMI, kg m−2) is associated with higher risk for disease. We wanted to investigate if BMI is related to clinico-pathological characteristics, hormone receptor status in primary tumour, and disease outcome in endometrial cancer. In total, 1129 women primarily treated for endometrial carcinoma at Haukeland University Hospital during 1981–2009 were studied. Body mass index was available for 949 patients and related to comprehensive clinical and histopathological data, hormone receptor status in tumour, treatment, and follow-up. High BMI was significantly associated with low International Federation of Gynaecology and Obstetrics (FIGO) stage, endometrioid histology, low/intermediate grade, and high level of progesterone receptor (PR) mRNA by qPCR (n=150; P=0.02) and protein expression by immunohistochemistry (n=433; P=0.003). In contrast, oestrogen receptor (ERα) status was not associated with BMI. Overweight/obese women had significantly better disease-specific survival (DSS) than normal/underweight women in univariate analysis (P=0.035). In multivariate analysis of DSS adjusting for age, FIGO stage, histological subtype, and grade, BMI showed no independent prognostic impact. High BMI was significantly associated with markers of non-aggressive disease and positive PR status in a large population-based study of endometrial carcinoma. Women with high BMI had significantly better prognosis in univariate analysis of DSS, an effect that disappeared in multivariate analysis adjusting for established prognostic markers. The role of PR in endometrial carcinogenesis needs to be further studied.
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影响因子：
6.2
作者：
Xu, Wang-Hong;Long, Ji-rong;Zheng, Wei;Ruan, Zhi-xian;Cai, Qiuyin;Cheng, Jia-rong;Xiang, Yong-Bing;Shu, Xiao-Ou
通讯作者：
Shu, Xiao-Ou
影响因子：
6.2
作者：
von Gruenigen, Vivian E.;Tian, Chunqiao;Barakat, Richard R.
通讯作者：
Barakat, Richard R.
影响因子：
4.7
作者：
Jeong, Nan-Hee;Lee, Jong-Min;Lee, Juneyoung
通讯作者：
Lee, Juneyoung
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
45.3
作者：
Salvesen, HB;Iversen, OE;Akslen, LA
通讯作者：
Akslen, LA