Low-dose droperidol suppresses transcranial electrical motor-evoked potential amplitude: a retrospective study
Low-dose droperidol suppresses transcranial electrical motor-evoked potential amplitude: a retrospective study
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小剂量氟哌利多抑制经颅电动诱发电位振幅：一项回顾性研究
DOI：
10.1007/s10877-020-00464-4
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发表时间：
2020
影响因子：
2.2
通讯作者：
Baba Hiroshi
中科院分区：
文献类型：
--
作者：
Deguchi Hiroyuki;Furutani Kenta;Mitsuma Yusuke;Kamiya Yoshinori;Baba Hiroshi
低剂量氟哌啶醇在手术中和手术后被广泛用作止吐剂。虽然高剂量氟哌啶醇影响运动诱发电位，但低剂量氟哌啶醇对运动诱发电位振幅的影响尚不清楚。本研究的目的是探讨低剂量氟哌啶醇是否影响运动诱发电位振幅。我们回顾性回顾了2016年2月至2017年2月在全身麻醉下接受脊柱手术并进行运动诱发电位监测的患者的数据。观察双侧拇短外展肌、胫前肌和幻觉外展肌在给予氟哌啶醇后1和1 - 2小时内的运动诱发电位振幅与基线运动诱发电位值的比较。对34例患者进行了分析。氟哌啶醇的中位剂量为21µg/kg。给药后各肌肉运动诱发电位幅值均显著降低，并在2 h内恢复至基线值。给药后各肌肉运动诱发电位幅值的降低幅度为基线值的37-45%。其他药物的使用没有显著差异。氟哌啶醇给药无严重不良反应。小剂量氟哌啶醇对运动诱发电位振幅有抑制作用。在脊柱外科术中进行运动诱发电位监测时，麻醉医师应注意氟哌啶醇的给药时机，即使是低剂量。基于本研究结果，我们正在进行一项随机对照试验。
Low-dose droperidol has been widely used as an antiemetic during and after surgery. Although high-dose droperidol affects motor-evoked potential, the effects of low-dose droperidol on motor-evoked potential amplitude are unclear. The aim of this study was to investigate whether low-dose droperidol affects motor-evoked potential amplitude. We retrospectively reviewed the data of patients who underwent spine surgery under general anesthesia with motor-evoked potential monitoring from February 2016 to 2017. The outcome was the motor-evoked potential amplitude of the bilateral abductor pollicis brevis muscle, tibialis anterior muscle, and abductor hallucis muscle within 1 and 1–2 h after droperidol administration, compared with the baseline motor-evoked potential value. Thirty-four patients were analyzed. The median dose of droperidol was 21 µg/kg. The motor-evoked potential amplitudes of all muscles were significantly reduced after droperidol administration and recovered to baseline values within 2 h. The reduction of all motor-evoked potential amplitudes after droperidol administration was 37–45% of baseline values. There were no significant differences in other drugs administered. There were no serious adverse effects of droperidol administration. Motor-evoked potential amplitude was suppressed by low-dose droperidol. During intraoperative motor-evoked potential monitoring in spine surgery, anesthesiologists should pay careful attention to the timing of administration of droperidol, even at low doses. Based on the results of this study, we are conducting a randomized controlled trial.
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影响因子：
8.8
作者：
Minto, CF;Schnider, TW;Shafer, SL
通讯作者：
Shafer, SL
氟哌利多对脊髓背角神经元中河豚毒素敏感钠通道的快速和慢速失活的差异阻滞
影响因子：
8.8
作者：
A. Olschewski;M. Bräu;G. Hempelmann;W. Vogel;B. V. Safronov
通讯作者：
B. V. Safronov
影响因子：
4.8
作者：
KALKMAN, CJ;DRUMMOND, JC;CHESNUT, RM
通讯作者：
CHESNUT, RM
影响因子：
8.8
作者：
SHAFER, SL;SIEGEL, LC;SCOTT, JC
通讯作者：
SCOTT, JC
神经乐普镇痛（滴周期醇-芬太尼）对经颅磁刺激诱发的猴子运动电位的影响。
影响因子：
3.7
作者：
R. Ghaly;James L. Stone;Walter J. Levy;R. Kartha;Edward A. Brunner;J. Aldrete;Ralf Laege
通讯作者：
Ralf Laege