Cell cycle RNA regulons coordinating early lymphocyte development.
Cell cycle RNA regulons coordinating early lymphocyte development.
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细胞周期RNA调节，协调早期淋巴细胞发育。
DOI：
10.1002/wrna.1419
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Turner M
中科院分区：
文献类型：
--
作者：
Galloway A;Turner M
Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post‐transcriptional and post‐translational regulators to determine the proteome. Furthermore, the post‐transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. WIREs RNA 2017, 8:e1419. doi: 10.1002/wrna.1419 For further resources related to this article, please visit the WIREs website.
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