Emerging Themes in Regulation of Global mRNA Turnover in cis.
Emerging Themes in Regulation of Global mRNA Turnover in cis.
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DOI：
10.1016/j.tibs.2016.08.014
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发表时间：
2017-01
影响因子：
13.8
通讯作者：
Shyu, Ann-Bin
中科院分区：
文献类型：
--
作者：
Chen, Chyi-Ying A.;Shyu, Ann-Bin
Messenger RNA (mRNA) is the molecule that conveys genetic information from DNA to the translation apparatus. mRNAs in all organisms display a wide range of stability, and mechanisms have evolved to selectively and differentially regulate individual mRNA stability in response to intra-cellular and extra-cellular cues. In recent years, three seemingly distinct aspects of RNA biology—mRNA N6-methyladenosine (m6A) modification, alternative 3’ end processing and polyadenylation (APA), and mRNA codon usage—have been linked to mRNA turnover, and all three aspects function to regulate global mRNA stability in cis. Here, we discuss the discovery and molecular dissection of these mechanisms in relation to how they impact the intrinsic decay rate of mRNA in eukaryotes, leading to transcriptome reprogramming.
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