Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.
Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.
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DOI：
10.1016/j.immuni.2013.01.015
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发表时间：
2013-05-23
期刊：
影响因子：
32.4
通讯作者：
Yuan, Junying
中科院分区：
文献类型：
--
作者：
Py, Benedicte F.;Gonzalez, Santiago F.;Long, Kai;Kim, Mi-Sung;Kim, Young-A.;Zhu, Hong;Yao, Jianhua;Degauque, Nicolas;Villet, Regis;Ymele-Leki, Patrick;Gadjeva, Mihaela;Pier, Gerald B.;Carroll, Michael C.;Yuan, Junying
Cochlin, an extracellular matrix protein, shares homologies with the Factor C, a serine protease found in horseshoe crabs, which is critical for anti-bacterial responses. Mutations in the COCH gene are responsible for human DFNA9 syndrome, a disorder characterized by neurodegeneration of inner ear that leads to hearing loss and vestibular impairments. The physiological function of cochlin, however, is unknown. Here, we report that cochlin is specifically expressed by follicular dendritic cells, and selectively localized in the fine extracellular network of conduits in the spleen and lymph nodes. During inflammation, cochlin was cleaved by aggrecanases and secreted into blood circulation. In models of lung infection with Pseudomonas aeruginosa and Staphylococcus aureus, Coch−/− mice show reduced survival linked to defects in local cytokine production, recruitment of immune effector cells and bacterial clearance. By producing cochlin, FDCs thus contribute to the innate immune response in defense against bacteria.
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滑膜巨噬细胞和巨噬细胞产生的细胞因子在驱动聚集蛋白聚糖酶、基质金属蛋白酶和骨关节炎中其他破坏性和炎症反应中的作用。
影响因子：
4.9
作者：
Bondeson J;Wainwright SD;Lauder S;Amos N;Hughes CE
通讯作者：
Hughes CE
影响因子：
2.5
作者：
Mizuta, Kunihiro;Ikezono, Tetsuo;Mineta, Hiroyuki
通讯作者：
Mineta, Hiroyuki
DOI：
10.1084/jem.20021801
发表时间：
2003-08-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Nolte MA;Beliën JA;Schadee-Eestermans I;Jansen W;Unger WW;van Rooijen N;Kraal G;Mebius RE
通讯作者：
Mebius RE
DOI：
10.1084/jem.192.10.1425
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gretz JE;Norbury CC;Anderson AO;Proudfoot AE;Shaw S
通讯作者：
Shaw S
影响因子：
4.4
作者：
Ariki, Shigeru;Takahara, Shusaku;Kawabata, Shun-ichiro
通讯作者：
Kawabata, Shun-ichiro