Adult hip dysplasia and osteoarthritis
Adult hip dysplasia and osteoarthritis
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成人髋关节发育不良和骨关节炎
DOI：
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
S. Jacobsen
中科院分区：
文献类型：
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作者：
S. Jacobsen
骨关节炎（OA）以全身和/或局部因素的相互作用为前提。在髋关节骨关节炎中，先天性或发育畸形被认为构成过早退化的个体危险因素。髋关节发育不良（HD）就是这样一种畸形。放射学和流行病学研究有几个目的： 严格评估哥本哈根心脏研究的放射源材料：骨关节炎子研究，包括 1994 年记录的 4,151 张标准化、承重骨盆 X 线照片。确定或取消放射源材料进一步研究的资格。开发一种可理解且可重复的髋部 OA 影像鉴别器，与自我报告的髋部疼痛尽可能密切相关。确定高加索城市背景人群中髋关节 OA 和 HD 的患病率，并调查性别、年龄、身体和职业参数对这些患病率的影响。相对于其他潜在危险因素，评估 HD 对髋关节 OA 发展的影响。评估发育不良髋部随时间的退化情况。评估HD的三维解剖结构和严重发育不良髋关节退行性特征的分布，并评估全髋关节置换手术的危险因素。在研究过程中，我们发现 HD 经典指标的评估受到 X 射线记录期间骨盆方向的显着影响，并确定了骨盆 X 光片旋转和倾斜/后仰的排除限制，以保持在 ± 3° 的测量误差范围内。我们发现，与复合放射学 OA 分类相比，最小关节间隙宽度 (JSW) ≤ 2.0mm 构成放射学髋关节 OA 鉴别器，具有优异的可重复性和临床相关性。我们记录了绝经后女性最小 JSW 逐渐下降的情况，而男性最小 JSW 在一生中保持相对不变。我们没有发现任何证据表明吸烟、职业性重复举重或超重会显着影响最小 JSW。 ≥ 60 岁受试者中髋部 OA 的患病率约为 5.5%，HD 患病率为 4-10%，具体取决于所采用的放射学标准。年龄和 HD 是女性髋部 OA 发生的重要危险因素，HD 是男性髋部 OA 发生的重要危险因素。然而，只有肥胖才能决定髋关节置换手术的发生。在对 81 名患有轻度或中度髋关节发育不良的受试者进行为期十年的纵向研究中，与 136 名对照受试者相比，我们没有记录到放射学退化的趋势。在一项对严重发育不良髋关节的计算机断层扫描研究中，我们发现髋臼前部容纳不足与股骨近端前倾角之间存在密切关系。发育不良的髋部退化的主要区域位于关节的前外侧象限。
Osteoarthritis (OA) presupposes the interaction of systemic and/or local factors. In hip joint OA, congenital or developmental malformation is believed to constitute an individual risk factor for premature degeneration. Hip dysplasia (HD) is such a malformation. The radiological and epidemiological studies had several aims: To critically evaluate the radiological source material of the Copenhagen Heart Study: The Osteoarthritis Substudy, consisting of 4,151 standardized, weight bearing pelvic radiographs recorded –1994. To qualify or disqualify the radiological source material for further studies. To develop a comprehensible and reproducible radiographic discriminator of hip OA with as close an association to self reported hip pain as possible. To identify prevalences of hip OA and HD in a Caucasian, urban background population and investigate the influence of sex, age, physical and occupational parameters on these prevalences. To evaluate the influence of HD on hip OA development relative to other potential risk factors. To evaluate degeneration in dysplastic hips over time. To evaluate the three dimensional anatomy of HD and the distribution of degenerative features in severely dysplastic hips, and To evaluate risk factors for total hip replacement surgery. In the course of the studies we found that assessments of classic indices of HD were significantly influenced by pelvic orientation during x-ray recording and identified exclusion limits of rotation and inclination/reclination of pelvic radiographs to stay inside a measurement error of ± 3°. We found that minimum joint space width (JSW) ≤ 2.0 mm constituted a radiologic hip OA discriminator of superior reproducibility and clinical relevance compared to composite, radiological OA classifications. We documented a progressive postmenopausal decline in female minimum JSW, while male minimum JSW remained relatively unaltered throughout life. We found no evidence that smoking, occupational exposure to repeated, heavy lifting or overweight significantly influenced minimum JSW. Prevalences of hip OA was approximately 5.5% in subjects ≥ 60 years of age, and HD prevalence was 4–10%, depending on the radiographic criteria applied. Age and HD were significant risk factors for hip OA development in women, and HD was found to be a significant risk factor for hip OA in men. However, only obesity was found to determine an event of hip replacement surgery. In a longitudinal study of 81 subjects with mild or moderate hip dysplasia followed for a decade we did not document a tendency for radiological degeneration compared to 136 control subjects. In a computerized tomographic study of severely dysplastic hips we found a close relationship between insufficient anterior, acetabular containment and proximal femoral anteversion. The primary area of degeneration in dysplastic hips was in the antero-lateral quadrant of the joint.
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影响因子：
--
作者：
FELSON, DT;ZHANG, YQ;LEVY, D
通讯作者：
LEVY, D
影响因子：
--
作者：
OLIVERIA, SA;FELSON, DT;WALKER, AM
通讯作者：
WALKER, AM
影响因子：
5.4
作者：
Oliveria, SA;Felson, DT;Walker, AM
通讯作者：
Walker, AM
老年女性的休闲体育活动和髋部骨关节炎的风险。
DOI：
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发表时间：
1999
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Lane,NE;Hochberg,MC;Pressman,A;Scott,JC;Nevitt,MC
通讯作者：
Nevitt,MC
影响因子：
--
作者：
FELSON, DT;ANDERSON, JJ;MEENAN, RF
通讯作者：
MEENAN, RF