Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation.
Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation.
复制标题
受体 IL-15 遗传变异与肝移植后 HBV 相关肝细胞癌预后之间的关联
DOI：
10.1155/2017/1754696
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Peng Z
中科院分区：
文献类型：
--
作者：
Zhang T;Liu Y;Peng X;Fan J;Peng Z
Objective To investigate the association of donor and recipient IL-15 genetic variants with HCC recurrence and prognosis after LT. Methods A total of 112 liver transplant patients with HBV-related HCC were enrolled. IL-15 rs10519613 and rs13122930 were genotyped in donors and recipients. Results Recipient IL-15 rs10519613 polymorphism was found to be significantly related to HCC recurrence after LT. In multivariate analysis, tumor thrombus, UCSF criteria, and recipient IL-15 rs10519613 genotypes were independent predictive factors of HCC recurrence after LT. Kaplan-Meier survival analysis demonstrated that patients with recipient IL-15 rs10519613 CA/AA genotypes had a decreased disease-free survival and overall survival than those with the CC genotype. Recipient IL-15 rs10519613 genetic variant could improve survival prediction when combined with the UCSF criteria. Furthermore, Cox proportional hazard regression analysis revealed that tumor size (p = 0.012, p = 0.623), tumor thrombus (p = 0.011, p = 0.015), UCSF criteria (p = 0.471, p = 0.013), and recipient IL-15 rs10519613 genotype (p = 0.039, p = 0.008) were independent factors of predicting DFS and OS. Conclusions Recipient IL-15 rs10519613 polymorphism was associated with HCC recurrence after LT and might be a potential genetic marker for the clinical outcome of HCC patients treated with LT.
登录
查看更多内容
影响因子：
44.1
作者：
Shi, YY;He, L
通讯作者：
He, L
DOI：
10.1158/1055-9965.epi-08-0962
发表时间：
2009-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Van Dyke AL;Cote ML;Wenzlaff AS;Chen W;Abrams J;Land S;Giroux CN;Schwartz AG
通讯作者：
Schwartz AG
影响因子：
5.1
作者：
Morris JC;Ramlogan-Steel CA;Yu P;Black BA;Mannan P;Allison JP;Waldmann TA;Steel JC
通讯作者：
Steel JC
影响因子：
9.7
作者：
Sun, Hongcheng;Teng, Mujian;Peng, Zhihai
通讯作者：
Peng, Zhihai
影响因子：
5.8
作者：
Fu, Yi-Peng;Yi, Yong;Qiu, Shuang-Jian
通讯作者：
Qiu, Shuang-Jian