Current trends in the use of liposomes for tumor targeting.
Current trends in the use of liposomes for tumor targeting.
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DOI：
10.2217/nnm.13.118
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Torchilin VP
中科院分区：
文献类型：
--
作者：
Deshpande PP;Biswas S;Torchilin VP
脂质体用于药物递送在药物纳米载体的历史早期就开始了。这些纳米尺寸的脂质双层囊泡由于其效率、生物相容性、非免疫原性、增强的化学治疗剂的溶解性以及它们包封多种药物的能力而成为流行的药物递送系统。被动和配体介导的主动靶向促进肿瘤特异性，同时减少不良脱靶效应。脂质体的当前领域集中于临床和诊断应用。最近的努力集中在多功能脂质体的发展，靶向细胞和细胞器与一个单一的交付系统。本文就脂质体在肿瘤靶向方面的研究进展作一综述。
The use of liposomes for drug delivery began early in the history of pharmaceutical nanocarriers. These nanosized, lipid bilayered vesicles have become popular as drug delivery systems owing to their efficiency, biocompatibility, nonimmunogenicity, enhanced solubility of chemotherapeutic agents and their ability to encapsulate a wide array of drugs. Passive and ligand-mediated active targeting promote tumor specificity with diminished adverse off-target effects. The current field of liposomes focuses on both clinical and diagnostic applications. Recent efforts have concentrated on the development of multifunctional liposomes that target cells and cellular organelles with a single delivery system. This review discusses the recent advances in liposome research in tumor targeting.
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