Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment
Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment
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新生皮质损伤后幼年和成年大鼠社交和游戏行为缺陷：慢性青春期大麻素治疗的影响
DOI：
10.1038/sj.npp.1300634
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发表时间：
2005
影响因子：
7.6
通讯作者：
M. Koch
中科院分区：
文献类型：
--
作者：
Miriam Schneider;M. Koch
本研究的目的是探讨新生儿内侧前额叶皮质（mPFC）兴奋性损伤的影响，社会发挥，社会行为无关的发挥，自我梳理在幼年和成年大鼠。我们还研究了大麻素激动剂WIN 55，212 -2（WIN）对青春期慢性治疗的行为影响，以检验早期病变使大脑在以后的生活中容易受到大麻素摄入的影响的假设。新生儿mPFC病变和青春期WIN治疗扰乱了青少年和成年大鼠的社会游戏，社会行为和自我梳理。此外，我们观察到更多的社会发挥行为，在光周期中的温治疗比溶剂治疗的大鼠。值得注意的是，手术和WIN治疗的组合破坏了损伤和假损伤大鼠的社会行为。目前的数据表明，mPFC是重要的，充分的青少年的反应选择的背景下，社会发挥，并可能参与发展的成年人的社会和非社会行为。此外，我们的数据进一步证明了大麻素系统参与焦虑和社会行为。还显示了新生儿手术引起的应激或皮质病变与青春期大麻素给药相结合的叠加效应。大鼠的社会和非社会行为障碍与早期额叶皮质损伤的症状以及人类的神经发育障碍（如精神分裂症和自闭症）相当。因此，我们建议结合新生儿皮质病变与青春期慢性大麻素管理作为研究神经精神疾病的社会功能受损的神经元机制的动物模型。
The aim of the present study was to investigate the effects of neonatal excitotoxic lesions of the medial prefrontal cortex (mPFC) on social play, social behavior unrelated to play, and self-grooming in juvenile and adult rats. We additionally examined the behavioral effects of chronic pubertal treatment with the cannabinoid agonist WIN 55,212-2 (WIN) in order to test the hypothesis that early lesions render the brain vulnerable to cannabinoid intake in later life. Neonatal mPFC lesions and pubertal WIN treatment disrupted social play, social behavior, and self-grooming in juvenile and adult rats. Additionally, we observed more social play behaviors during light cycle in WIN-treated than in vehicle-treated rats. Notably, the combination of surgery and WIN treatment disrupted social behavior in lesioned and sham-lesioned rats. The present data indicate that the mPFC is important for adequate juvenile response selection in the context of social play and might be involved in the development of adult social and nonsocial behavior. Moreover, our data add further evidence for an involvement of the cannabinoid system in anxiety and social behavior. Additive effects of neonatal surgery-induced stress or cortical lesions in combination with pubertal cannabinoid administration are also shown. The disturbances of social and nonsocial behavior in rats are comparable to symptoms of early frontal cortex damage, as well as neurodevelopmental disorders in humans, such as schizophrenia and autism. Therefore, we propose the combination of neonatal cortical lesions with chronic cannabinoid administration during puberty as an animal model for studying neuronal mechanisms of impaired social functioning in neuropsychiatric disorders.
精神分裂症的区域多样化皮质病理学：该疾病病因学的线索。
影响因子：
6.6
作者：
Selemon,LD
通讯作者：
Selemon,LD
新生儿冷冻麻醉会影响成年大鼠视觉皮层的形态。
DOI：
10.1016/s0165-3806(98)00125-4
发表时间：
1998
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Nuñez,JL;Kim,BY;Juraska,JM
通讯作者：
Juraska,JM
影响因子：
3.7
作者：
De Bellis, MD;Keshavan, MS;Boring, AM
通讯作者：
Boring, AM