Demystifying particle-based oral vaccines.
Demystifying particle-based oral vaccines.
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DOI：
10.1080/17425247.2021.1946511
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发表时间：
2021-10
影响因子：
6.6
通讯作者：
Gill HS
中科院分区：
文献类型：
--
作者：
Gonzalez-Cruz P;Gill HS
口服接种途径是无痛和无针的，可以诱导全身和粘膜免疫。然而，胃肠道屏障和抗原降解给口服疫苗的开发带来了重大障碍。减毒活病毒和细菌可以克服这些障碍，但有引入安全问题的风险。作为替代方案，已经研究了用于抗原保护和递送的颗粒，但是没有FDA批准的基于基于颗粒的递送系统的口服疫苗。我们的目标是发现潜在的决定因素，可以解释目前的不足之处，并确定范式，可以在未来成功开发口服疫苗依赖于基于颗粒的输送系统。我们回顾了与使用颗粒进行口服疫苗接种相关的文献，并特别强调了制剂特征和给药方案，以深入了解这些参数如何影响全身和粘膜隔室中抗原特异性抗体的产生。尽管疫苗的历史悠久，但基于颗粒的口服疫苗接种是一个相对较新的领域，第一项研究发表于1989年。不同研究之间在给药方案、给药次数和每剂疫苗量方面存在显著差异。大多数研究未在制剂中使用佐剂。需要更好地标准化疫苗接种参数，以改善实验之间的比较，佐剂应用于增强全身和粘膜免疫应答，并减少剂量，这将使口服疫苗更具吸引力。
The oral route of vaccination is pain- and needle-free and can induce systemic and mucosal immunity. However, gastrointestinal barriers and antigen degradation impose significant hurdles in the development of oral vaccines. Live attenuated viruses and bacteria can overcome these barriers but at the risk of introducing safety concerns. As an alternative, particles have been investigated for antigen protection and delivery, yet there are no FDA-approved oral vaccines based on particle-based delivery systems. Our objective was to discover underlying determinants that can explain the current inadequacies and identify paradigms that can be implemented in future for successful development of oral vaccines relying on particle-based delivery systems. We reviewed literature related to the use of particles for oral vaccination and placed special emphasis on formulation characteristics and administration schedules to gain an insight into how these parameters impact production of antigen-specific antibodies in systemic and mucosal compartments. Despite the long history of vaccines, particle-based oral vaccination is a relative new field with the first study published in 1989. Substantial variability exists between different studies with respect to dosing schedules, number of doses, and the amount of vaccine per dose. Most studies have not used adjuvants in the formulations. Better standardization in vaccination parameters is required to improve comparison between experiments, and adjuvants should be used to enhance the systemic and mucosal immune responses and to reduce the number of doses, which will make oral vaccines more attractive.
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
5.5
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通讯作者：
D'Souza, Martin J.
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4.6
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
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