Size for gestational age affects the risk for type 1 diabetes in children and adolescents: a Swedish national case-control study.
Size for gestational age affects the risk for type 1 diabetes in children and adolescents: a Swedish national case-control study.
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DOI：
10.1007/s00125-021-05381-y
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发表时间：
2021-05
期刊：
影响因子：
8.2
通讯作者：
Samuelsson U
中科院分区：
文献类型：
--
作者：
Lindell N;Bladh M;Carlsson A;Josefsson A;Aakesson K;Samuelsson U
环境因素被认为是导致1型糖尿病风险的原因之一。这项研究的目的是调查胎龄大小如何影响患儿童期1型糖尿病的风险。使用瑞典儿科糖尿病质量登记和瑞典医学出生登记，2000年至2012年诊断为1型糖尿病的儿童(n = 9376)与4名对照儿童(n = 37,504)进行匹配。根据瑞典国家标准定义小于胎龄(SGA)和大于胎龄(LGA)。数据最初使用皮尔逊的χ2进行分析，然后通过单因素和多因素Logistic回归模型进行分析。出生时与胎龄相适应的儿童比例相同，但与对照组儿童相比，1型糖尿病儿童出生LGA的几率更高，出生SGA的几率更低(分别为4.7%比3.5%和2.0%比2.6%，p <； 0.001)。在多因素Logistic回归分析中，出生时LGA增加(调整OR 1.16[95%CI 1.02，1.32])，SGA减少(调整OR 0.76[95%CI 0.63，0.92])，与母亲BMI和糖尿病无关。瑞典儿童的胎龄大小会影响1型糖尿病的风险，如果孩子出生在LGA，风险会增加，如果孩子出生SGA，风险会降低。出生LGA是1型糖尿病的独立危险因素，与母亲的BMI和糖尿病无关。因此，降低出生LGA的风险可能在一定程度上降低患1型糖尿病的风险。
Environmental factors are believed to contribute to the risk of developing type 1 diabetes. The aim of this study was to investigate how size for gestational age affects the risk of developing childhood type 1 diabetes. Using the Swedish paediatric diabetes quality register and the Swedish medical birth register, children with type 1 diabetes diagnosed between 2000 and 2012 (n = 9376) were matched with four control children (n = 37,504). Small for gestational age (SGA) and large for gestational age (LGA) were defined according to Swedish national standards. Data were initially analysed using Pearson’s χ2 and thereafter by single and multiple logistic regression models. An equal proportion of children were born appropriate for gestational age, but children with type 1 diabetes were more often born LGA and less often born SGA than control children (4.7% vs 3.5% and 2.0% vs 2.6%, respectively, p < 0.001). In the multiple logistic regression analysis, being born LGA increased (adjusted OR 1.16 [95% CI 1.02, 1.32]) and SGA decreased (adjusted OR 0.76 [95% CI 0.63, 0.92]) the risk for type 1 diabetes, regardless of maternal BMI and diabetes. Size for gestational age of Swedish children affects the risk of type 1 diabetes, with increased risk if the child is born LGA and decreased risk if the child is born SGA. Being born LGA is an independent risk factor for type 1 diabetes irrespective of maternal BMI and diabetes. Thus, reducing the risk for a child being born LGA might to some extent reduce the risk for type 1 diabetes.
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影响因子：
8.2
作者：
Cardwell, C. R.;Stene, L. C.;Patterson, C. C.
通讯作者：
Patterson, C. C.
影响因子：
3.5
作者：
Cardwell, CR;Carson, DJ;Patterson, CC
通讯作者：
Patterson, CC
影响因子：
2.1
作者：
Rasmussen, Kathleen M.;Catalano, Patrick M.;Yaktine, Ann L.
通讯作者：
Yaktine, Ann L.
影响因子：
--
作者：
Dahlquist, G;Bennich, SS;Kallen, B
通讯作者：
Kallen, B
影响因子：
3.5
作者：
Algert, C. S.;McElduff, A.;Roberts, C. L.
通讯作者：
Roberts, C. L.