Continuous Theta-Burst Stimulation Intensity Dependently Facilitates Motor-Evoked Potentials Following Focal Electrical Stimulation of the Rat Motor Cortex.
Continuous Theta-Burst Stimulation Intensity Dependently Facilitates Motor-Evoked Potentials Following Focal Electrical Stimulation of the Rat Motor Cortex.
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DOI：
10.3389/fncir.2020.585624
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发表时间：
2020
影响因子：
3.5
通讯作者：
Fudaba H
中科院分区：
文献类型：
--
作者：
Fujiki M;Kawasaki Y;Fudaba H
尽管已知θ突发刺激（TBS）会根据人类的刺激条件来差异性地改变运动皮层的兴奋性，但在动物（特别是大鼠）中是否可以看到类似的效果仍有待确定。鉴于实验大鼠模型对人类的重要性，本研究探索了大鼠的这种刺激范例。具体来说，本研究旨在探讨麻醉动物 TBS 后皮质脊髓的兴奋性，以确认其与人类结果的可比性。评估了使用配对电刺激方案的抑制促进配置以及 TBS 范例对大鼠下行运动通路中运动诱发电位 (MEP) 的影响。在美托咪定/咪达唑仑/布托啡诺 (MMB) 麻醉下，配对刺激 MEP 显示抑制 [刺激间隔 (ISI)：3 ms] 和促进 (11 ms) 模式。此外，虽然氯胺酮和甲苯噻嗪 (K/X) 麻醉完全阻断了 11 毫秒 ISI 的促进作用，但保留了 3 毫秒 ISI 的抑制作用。连续和间歇 TBS 根据刺激强度强烈促进 MEP，在 MMB 和 K/X 麻醉下持续长达 25 分钟。这些发现类似于使用配对脉冲磁刺激在人类运动皮层中观察到的皮质内抑制和促进，特别是谷氨酸介导的促进阶段。然而，大鼠运动皮层中存在不同的 TBS 促进机制。这些不同的 TBS 促进机制影响大鼠和人类模型之间 TBS 的可比性和解释。
Although theta-burst stimulation (TBS) is known to differentially modify motor cortical excitability according to stimulus conditions in humans, whether similar effects can be seen in animals, in particular rats, remains to be defined. Given the importance of experimental rat models for humans, this study explored this stimulation paradigm in rats. Specifically, this study aimed to explore corticospinal excitability after TBS in anesthetized animals to confirm its comparability with human results. Both inhibition-facilitation configurations using paired electrical stimulation protocols and the effects of the TBS paradigm on motor-evoked potentials (MEPs) in rat descending motor pathways were assessed. Paired-stimulation MEPs showed inhibition [interstimulus interval (ISI): 3 ms] and facilitation (11 ms) patterns under medetomidine/midazolam/butorphanol (MMB) anesthesia. Furthermore, while ketamine and xylazine (K/X) anesthesia completely blocked facilitation at 11-ms ISI, inhibition at a 3-ms ISI was preserved. Continuous and intermittent TBS strongly facilitated MEPs depending on stimulus intensity, persisting for up to 25 min under both MMB and K/X anesthesia. These findings are similar to the intracortical inhibition and facilitation observed in the human motor cortex using paired-pulse magnetic stimulation, particularly the glutamate-mediated facilitation phase. However, different TBS facilitatory mechanisms occur in the rat motor cortex. These different TBS facilitatory mechanisms affect the comparability and interpretations of TBS between rat and human models.
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DOI：
10.1113/jp274663
发表时间：
2017-11-15
期刊：
The Journal of physiology
影响因子：
--
作者：
Mishra AM;Pal A;Gupta D;Carmel JB
通讯作者：
Carmel JB
影响因子：
5.3
作者：
Barry, Melissa D.;Boddington, Laura J.;Reynolds, John N. J.
通讯作者：
Reynolds, John N. J.
神经元网络在驱动人类运动皮层可塑性中的作用
影响因子：
3.7
作者：
Hamada, Masashi;Murase, Nagako;Rothwelll, John C.
通讯作者：
Rothwelll, John C.
影响因子：
2.5
作者：
Hsieh, Tsung-Hsun;Dhamne, Sameer C.;Rotenberg, Alexander
通讯作者：
Rotenberg, Alexander
影响因子：
3
作者：
Rothwell, JC
通讯作者：
Rothwell, JC