Is hippocampal remapping the physiological basis for context?
Is hippocampal remapping the physiological basis for context?
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DOI：
10.1002/hipo.23160
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发表时间：
2020-08
期刊：
影响因子：
3.5
通讯作者：
Fenton AA
中科院分区：
文献类型：
--
作者：
Kubie JL;Levy ERJ;Fenton AA
1980年，Nadel和Wilner推广了Richard Hirsh的海马体创造环境表征的概念，称为“语境”，提出语境的基本结构是O‘Keefe和Nadel的里程碑式著作《作为认知图的海马体》(1978)提出的空间表征。反过来，这本书又源于这样一个发现，即单个海马神经元充当位置细胞，整个位置细胞集平铺成一个围墙，形成一种类型的空间地图。研究发现，独特的环境具有独特的位置细胞表征。也就是说，如果一个人拿到了特定环境的海马区地图，当动物被放在不同的环境中时，这种表征就会扰乱，或者“重新映射”。一些作者推测，“映射”和“重新映射”构成了语境和语境转换的生理基础。这个定义的一个困难是它完全是空间的；它只能在动物在围栏里运动时才能推断出来。本文的写作目的有五个。第一个是给出背景作为控制行为的变量的历史回顾。第二个目标是给出位置单元映射和重新映射概念的历史概述。第三个目标是提出基于时间而不是空间重叠的地点单元地图的更新定义，这增加了灵活性。第四个目标是解决这样一个问题，即海马体重新映射的生物现象是否实际上是背景心理现象变化的底物。最终目的是推测语境表征如何有助于有效的行为。
In 1980, Nadel and Wilner extended Richard Hirsh's notion that the hippocampus creates environmental representations, called “contexts,” suggesting that the fundamental structure of context was the spatial representation proposed by O'Keefe and Nadel's landmark book, The Hippocampus as a Cognitive Map (1978). This book, in turn, derives from the discovery that individual hippocampal neurons act as place cells, with the complete set of place cells tiling an enclosure, forming a type of spatial map. It was found that unique environments had unique place cell representations. That is, if one takes the hippocampal map of a specific environment, this representation scrambles, or “remaps” when the animal is placed in a different environment. Several authors have speculated that “maps” and “remapping” form the physiological substrates for context and context shifting. One difficulty with this definition is that it is exclusively spatial; it can only be inferred when an animal locomotes in an enclosure. There are five aims for this article. The first is to give an historical overview of context as a variable that controls behavior. The second aim is to give an historical overview of concepts of place cell maps and remapping. The third aim is to propose an updated definition of a place cell map, based on temporal rather than spatial overlaps, which adds flexibility. The fourth aim is to address the issue of whether the biological phenomenon of hippocampal remapping, is, in fact, the substrate for shifts in the psychological phenomenon of context. The final aim is speculation of how contextual representations may contribute to effective behavior.
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影响因子：
16.2
作者：
Bush D;Barry C;Manson D;Burgess N
通讯作者：
Burgess N
DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
影响因子：
25
作者：
Dombeck, Daniel A.;Harvey, Christopher D.;Tian, Lin;Looger, Loren L.;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
2.5
作者：
Csicsvari, J;Henze, DA;Buzsáki, G
通讯作者：
Buzsáki, G
影响因子：
5.3
作者：
Kao, Hsin-Yi;Dvorak, Dino;Fenton, Andre A.
通讯作者：
Fenton, Andre A.