Role of Selective Autophagy in Spermatogenesis and Male Fertility.
Role of Selective Autophagy in Spermatogenesis and Male Fertility.
复制标题
选择性自噬在精子发生和男性生育能力中的作用
作者：
Lv C;Wang X;Guo Y;Yuan S
Autophagy is a “self-eating” process that engulfs cellular contents for their subsequent digestion in lysosomes to engage the metabolic need in response to starvation or environmental insults. According to the contents of degradation, autophagy can be divided into bulk autophagy (non-selective autophagy) and selective autophagy. Bulk autophagy degrades non-specific cytoplasmic materials in response to nutrient starvation while selective autophagy targets specific cargoes, such as damaged organelles, protein aggregates, and intracellular pathogens. Selective autophagy has been documented to relate to the reproductive processes, especially for the spermatogenesis, fertilization, and biosynthesis of testosterone. Although selective autophagy is vital in the field of reproduction, its role and the underlying mechanism have remained unclear. In this review, we focus on selective autophagy to discuss the recent advances in our understanding of the mechanism and role of selective autophagy on spermatogenesis and male fertility in mammals. Understanding the role of selective autophagy during spermatogenesis will promote the recognition of genetic regulation in male infertility, and shed light on therapies of infertile patients.
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影响因子：
9
作者：
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DOI：
10.18632/aging.101070
发表时间：
2016-10-16
期刊：
Aging
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DOI：
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发表时间：
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期刊：
AUTOPHAGY: BIOLOGY AND DISEASES: BASIC SCIENCE
影响因子：
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