Role of Th22 Cells in Human Viral Diseases.
Role of Th22 Cells in Human Viral Diseases.
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Th22 细胞在人类病毒性疾病中的作用
DOI：
10.3389/fmed.2021.708140
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发表时间：
2021
影响因子：
3.9
通讯作者：
Cui D
中科院分区：
文献类型：
--
作者：
Gong J;Zhan H;Liang Y;He Q;Cui D
幼稚的CD4+ T细胞在接受抗原刺激后可分化为不同的细胞亚群，分泌相应的特征性细胞因子，从而在各种疾病中发挥生物学作用。Th22细胞是CD4+ T细胞的一个新亚群，不同于近年来发现的Th1、Th2、Th17和Treg细胞亚群。它们可以表达CCR4、CCR6和CCR10分子，分泌IL-22、IL-13和TNF-α。它们不能分泌IL-17、IL-4和干扰素-γ (IFN-γ)。IL-22被认为是Th22细胞的主要效应分子，其调节细胞分化的功能和机制不断完善。本文就Th22细胞的起源、分化等方面作一综述。此外，我们还描述了Th22细胞与Th17、Th1和Th2细胞之间的相互关系。此外，我们还讨论了Th22细胞在人类病毒感染疾病中的作用，这将为人类病毒感染的预防和治疗提供新的见解。
Naive CD4+ T cells can differentiate into different cell subsets after receiving antigen stimulation, which secrete corresponding characteristic cytokines and thereby exert biological effects in various diseases. Th22 cells, a novel subset of CD4+ T cells, are different from Th1, Th2, Th17, and Treg cell subsets, which have been discovered in recent years. They can express CCR4, CCR6, and CCR10 molecules and secrete IL-22, IL-13, and TNF-α. They are not able to secrete IL-17, IL-4, and interferon-γ (IFN-γ). IL-22 is considered as a major effector molecule of Th22 cells whose functions and mechanisms of regulating cell differentiation have been constantly improved. In this review, we provide an overview of the origin, differentiation of Th22 cells. Moreover, we also describe the interrelationships between Th22 cells and Th17, Th1, and Th2 cells. Additionally, the role of Th22 cells were discussed in human diseases with virus infection, which will provide novel insight for the prevention and treatment of viral infection in human.
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影响因子：
64.5
作者：
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通讯作者：
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