Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation.
Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation.
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人脑衰老的认知相关性:定量磁共振成像研究。
DOI:
10.1176/jnp.13.4.471
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发表时间:
2001
期刊:
影响因子:
--
通讯作者:
Lucke,JF
中科院分区:
文献类型:
--
作者:
Coffey,CE;Ratcliff,G;Saxton,JA;Bryan,RN;Fried,LP;Lucke,JF
The relations between age-related changes in brain structure and neuropsychological test performance in 320 elderly nonclinical volunteers (ages 66–90) were examined by using quantitative MRI data and measures of attention, information processing speed, language, memory, and visuospatial ability. Final path analyses revealed significant brain–behavior relationships for two of the six cognitive measures: the Trail Making Test part B and visual delayed memory. Poorer performance on Trails B was associated with smaller cerebral hemisphere volumes and larger volumes of peripheral CSF, lateral ventricles, and third ventricle. Poorer recall on visual delayed memory was associated with larger volumes of the lateral ventricles and third ventricle. The findings demonstrate a relationship between age-related changes in brain structure and an age-related decline in attention, psychomotor speed, and visual delayed memory. The neurobiological basis for this relationship requires further investigation.
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