Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation.

Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation.
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人脑衰老的认知相关性:定量磁共振成像研究。

DOI:
10.1176/jnp.13.4.471
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发表时间:
2001
期刊:
The Journal of neuropsychiatry and clinical neurosciences.
影响因子:
--
通讯作者:
Lucke,JF
Lucke,JF
中科院分区:
--
文献类型:
--
作者:
Coffey,CE;Ratcliff,G;Saxton,JA;Bryan,RN;Fried,LP;Lucke,JF

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采用定量MRI数据和注意、信息处理速度、语言、记忆和视觉空间能力的测量方法,研究了320名老年非临床志愿者(年龄66-90岁)脑结构的年龄相关变化与神经心理测试成绩之间的关系。最后的路径分析显示显着的脑行为关系的六个认知措施:连线测试部分B和视觉延迟记忆。Trails B的患者表现与大脑半球体积较小和外周CSF、侧脑室和第三脑室体积较大相关。视觉延迟记忆的后回忆与侧脑室和第三脑室体积增大有关。研究结果表明,与年龄相关的大脑结构变化与年龄相关的注意力下降,心理速度和视觉延迟记忆之间存在关系。这种关系的神经生物学基础需要进一步研究。
The relations between age-related changes in brain structure and neuropsychological test performance in 320 elderly nonclinical volunteers (ages 66–90) were examined by using quantitative MRI data and measures of attention, information processing speed, language, memory, and visuospatial ability. Final path analyses revealed significant brain–behavior relationships for two of the six cognitive measures: the Trail Making Test part B and visual delayed memory. Poorer performance on Trails B was associated with smaller cerebral hemisphere volumes and larger volumes of peripheral CSF, lateral ventricles, and third ventricle. Poorer recall on visual delayed memory was associated with larger volumes of the lateral ventricles and third ventricle. The findings demonstrate a relationship between age-related changes in brain structure and an age-related decline in attention, psychomotor speed, and visual delayed memory. The neurobiological basis for this relationship requires further investigation.
老年人计算机断层扫描:1.正常人群
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