Exploration of associations between deliberate self-poisoning and psychiatric disorders in rural Sri Lanka: A case-control study.

Exploration of associations between deliberate self-poisoning and psychiatric disorders in rural Sri Lanka: A case-control study.
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DOI:
10.1371/journal.pone.0255805
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发表时间:
2021
期刊:
影响因子:
3.7
通讯作者:
Rajapakse TN
Rajapakse TN
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Pushpakumara PHGJ;Dawson AH;Adikari AMP;Thennakoon SUB;Abeysinghe R;Rajapakse TN

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精神障碍是故意自残的重要预测因素。本研究旨在确定斯里兰卡农村农业区的DSM-IV、TR、Axis-I和II障碍与故意自毒(DSP)之间的关系。居住在该地区的患者被随机选为研究对象。根据专家精神病学家进行的DSM-IV-TR轴I和II障碍结构化临床访谈(SCID I&II),对病例和年龄、性别以及居住地区的配对对照进行了DSM-IV轴-I和II障碍的评估。男性208例(47.4%),女性231例(52.6%)。超过三分之一(37%)的男性和超过一半(53.7%)的女性年龄在20岁以下。89例(20.3%)患者和14例(3.2%)对照组被诊断为DSM-IV、TR轴-I和/或轴-II。有DSM-IV TrAXI诊断的患者比没有精神诊断的患者(32岁和19岁)年龄更大,p<0.0001。有抑郁发作与患DSP的风险增加19倍相关。作为一名年龄在30岁的男性,有酒精使用障碍的风险是男性的21倍。在10-19岁的边缘人格特征的女性中,发现DSP的超额风险是5倍。抑郁障碍和酒精相关障碍与患有DSP的老年参与者显著相关。与西方和该区域其他国家报告的发病率相比,斯里兰卡农村地区与数字信号处理器有关的精神障碍的总体流行率要低得多。因此,斯里兰卡减少自我伤害的健康和研究优先事项应侧重于与数字信号处理器有关的精神和非精神因素。
Psychiatric disorders are important predictors of deliberate self-harm. The present study was carried out to determine the associations between DSM-IV TR Axis- I & II disorders and deliberate self-poisoning (DSP) in a rural agricultural district in Sri Lanka. Patients residing in the district who presented with DSP were randomly selected for the study. Both the cases and age, sex, and, residential area, matched controls were assessed for DSM-IV TR Axis- I & II disorders based on the Structured Clinical Interview for DSM-IV-TR Axis I and II Disorders (SCID I & II) conducted by a specialist psychiatrist. Cases consisted of 208 (47.4%) males and 231 (52.6%) females. More than one third (37%) of males and more than half (53.7%) of females were aged below 20 years. DSM-IV TR axis-I and/or II psychiatric diagnoses were diagnosed in 89 (20.3%) of cases and 14 (3.2%) controls. Cases with a DSM-IV TR axis-I diagnosis were older than the cases without psychiatric diagnosis (32 and 19 years), p<0.0001. Having a depressive episode was associated with a 19 times higher risk for DSP. Being a male aged > = 30 years and having an alcohol use disorder carried a 21 times excess risk for DSP. A fivefold excess risk for DSP was found among 10–19 year old females with borderline personality traits. Depressive disorder and alcohol-related disorders were significantly associated with the older participants who presented with DSP. The overall prevalence of psychiatric disorders associated with DSP in rural Sri Lanka was significantly lower compared to the rates reported in the West and other countries in the region. Therefore, health and research priorities to reduce self-harm in Sri Lanka should focus both on psychiatric and non-psychiatric factors associated with DSP.
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