Piercing the fog of the RNA structure-ome.
Piercing the fog of the RNA structure-ome.
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DOI：
10.1126/science.abk1971
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发表时间：
2021-08-27
期刊：
影响因子：
--
通讯作者：
Weeks KM
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文献类型：
--
作者：
Weeks KM
RNA is distinct among large biomolecules in that it has both informational coding ability, carried in its sequence, and the ability to form complex three-dimensional structures that can have catalytic and regulatory roles. The information-carrying component is widely appreciated. The pattern of base pairing—the first level of RNA structure—can be experimentally assessed and modeled with impressive accuracy (, ). By contrast, our understanding of the extent and roles of complex three-dimensional RNA structures remains rudimentary. RNA viral genomes are rich in motifs with complex three-dimensional structures with regulatory functions , and evidence increasingly supports the hypothesis that functional RNA structures are ubiquitous in organisms ranging from bacteria to humans. However, developing and testing hypotheses about the roles of RNA structure have been hindered by the inability to identify and model these structures. On page 1047 of this issue, Townshendet al.report a machine-learning strategy for identifying native-like RNA folds.
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