The effects of statins in patients with advanced-stage cancers - a systematic review and meta-analysis.

The effects of statins in patients with advanced-stage cancers - a systematic review and meta-analysis.
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DOI:
10.3389/fonc.2023.1234713
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发表时间:
2023
影响因子:
4.7
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
作者:

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他汀类药物治疗已被证明可以降低多种癌症类型和总体阶段的死亡率。尽管如此,其在提高晚期癌症患者生存率方面的功效仍存在不确定性。我们对所有研究的数据进行了荟萃分析,比较了接受他汀类药物治疗的晚期癌症患者的总生存期、癌症特异性生存期和无进展生存期的风险比。研究选自 PubMed、Embase 和 Web of Science 数据库,从建库到 2022 年 12 月 31 日。癌症类型仅限于年度检查期间很少筛查且更有可能发展为晚期的癌症类型,例如肺癌、胰腺癌和卵巢癌。这导致 27 项研究符合荟萃分析的条件。他汀类药物治疗与总生存风险降低 26%(HR,0.74;95% CI,0.67,0.81)、癌症特异性生存风险降低 26%(HR,0.74;95% CI,0.61-0.88)以及无进展生存风险降低 24%(HR,0.76;95% CI, 0.65-0.87) 对于晚期癌症 患者。这些关联并未因研究设计、研究区域、癌症类型或其他医疗保健而减弱或加强。同时使用其他抗癌药物不会导致混杂效应。他汀类药物治疗对总体生存率和癌症特异性生存率产生显着的益处。尽管其益处可能低于已批准的免疫治疗药物,但其成本效益可能会导致严重的健康后果。在未来的临床试验中强烈建议同时使用他汀类药物作为癌症治疗方法。
Statin therapy has been shown to reduce mortality in a wide range of cancer types and overall stages. Still, there is uncertainty about its efficacy in increasing survival among advanced cancer patients. We conducted a meta-analysis with data from all studies that compared the hazard ratio of overall survival, cancer-specific survival, and progression-free survival in patients with advanced-stage cancer who receive statin therapy. Studies were selected from the PubMed, Embase, and Web of Science databases from their inception to December 31, 2022. Cancer types are limited to those rarely screened during the annual examination and more likely to develop into advanced stages, such as lung, pancreatic and ovarian cancers. This resulted in 27 studies eligible for meta-analysis. Statin therapy was associated with a 26% decreased risk of overall survival (HR, 0.74; 95% CI, 0.67, 0.81), 26% decreased risk of cancer-specific survival (HR, 0.74; 95% CI, 0.61-0.88), and 24% decreased risk of progression-free survival (HR, 0.76; 95% CI, 0.65-0.87) for advanced-stage cancer patients. The associations were not attenuated or reinforced by study design, study regions, cancer types, or other medical care. Concomitant use of other anticancer medications did not result in confounding effects. Statin therapy produces significant benefits on overall survival and cancer-specific survival. Although the benefits might be lower than the approved immunotherapy medications, its cost-effectiveness could lead to dramatic health consequences. Concomitant use of statin drugs as cancer treatments is highly recommended in future clinical trials.
DOI: 10.2183/pjab.86.484
发表时间: 2010
期刊: Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子: --
作者:
Endo A
通讯作者: Endo A
DOI: 10.1016/s0140-6736(10)60310-8
发表时间: 2010-11-13
期刊: LANCET
影响因子: 168.9
作者:
Armitage, Jane;Bowman, Louise;Wallendszus, Karl;Bulbulia, Richard;Rahimi, Kazem;Haynes, Richard;Parish, Sarah;Peto, Richard;Collins, Rory;Meade, T.;Sleight, P.;Collins, R.;Armitage, J.;Bowman, L.;Parish, S.;Peto, R.;Barton, J.;Bray, C.;Wincott, E.;Dayanandan, R.;Clarke, R.;Graham, I.;Simpson, D.;Warlow, C.;Wilken, D.;Tobert, J.;Mushner, T.;Doll, R.;Wilhelmsen, L.;Fox, K.;Hill, C.;Sandercock, P.;Webster, J.;Henderson, J.;Nixon, A.;Lackie, S.;Thompson, J.;Brown, M.;Blackwood, S.;Morgan, M.;Rhoden, W.;Saeed, B.;Houghton, M.;Nicholson, A.;Simpson, C.;Hoburn, B.;Cooper, I.;Gallivan, A.;Pickerell, E.;Hancock, J.;Watkinson, J.;Ryder, B.;Jones, S.;Burbridge, W.;Kitchen, M.;Leary, H. 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影响因子: --
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影响因子: --
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