The effects of statins in patients with advanced-stage cancers - a systematic review and meta-analysis.
The effects of statins in patients with advanced-stage cancers - a systematic review and meta-analysis.
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DOI:
10.3389/fonc.2023.1234713
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发表时间:
2023
影响因子:
4.7
通讯作者:
中科院分区:
文献类型:
--
作者:
Statin therapy has been shown to reduce mortality in a wide range of cancer types and overall stages. Still, there is uncertainty about its efficacy in increasing survival among advanced cancer patients. We conducted a meta-analysis with data from all studies that compared the hazard ratio of overall survival, cancer-specific survival, and progression-free survival in patients with advanced-stage cancer who receive statin therapy. Studies were selected from the PubMed, Embase, and Web of Science databases from their inception to December 31, 2022. Cancer types are limited to those rarely screened during the annual examination and more likely to develop into advanced stages, such as lung, pancreatic and ovarian cancers. This resulted in 27 studies eligible for meta-analysis. Statin therapy was associated with a 26% decreased risk of overall survival (HR, 0.74; 95% CI, 0.67, 0.81), 26% decreased risk of cancer-specific survival (HR, 0.74; 95% CI, 0.61-0.88), and 24% decreased risk of progression-free survival (HR, 0.76; 95% CI, 0.65-0.87) for advanced-stage cancer patients. The associations were not attenuated or reinforced by study design, study regions, cancer types, or other medical care. Concomitant use of other anticancer medications did not result in confounding effects. Statin therapy produces significant benefits on overall survival and cancer-specific survival. Although the benefits might be lower than the approved immunotherapy medications, its cost-effectiveness could lead to dramatic health consequences. Concomitant use of statin drugs as cancer treatments is highly recommended in future clinical trials.
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DOI:
10.2183/pjab.86.484
发表时间:
2010
期刊:
Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子:
--
作者:
Endo A
通讯作者:
Endo A
影响因子:
168.9
作者:
Armitage, Jane;Bowman, Louise;Wallendszus, Karl;Bulbulia, Richard;Rahimi, Kazem;Haynes, Richard;Parish, Sarah;Peto, Richard;Collins, Rory;Meade, T.;Sleight, P.;Collins, R.;Armitage, J.;Bowman, L.;Parish, S.;Peto, R.;Barton, J.;Bray, C.;Wincott, E.;Dayanandan, R.;Clarke, R.;Graham, I.;Simpson, D.;Warlow, C.;Wilken, D.;Tobert, J.;Mushner, T.;Doll, R.;Wilhelmsen, L.;Fox, K.;Hill, C.;Sandercock, P.;Webster, J.;Henderson, J.;Nixon, A.;Lackie, S.;Thompson, J.;Brown, M.;Blackwood, S.;Morgan, M.;Rhoden, W.;Saeed, B.;Houghton, M.;Nicholson, A.;Simpson, C.;Hoburn, B.;Cooper, I.;Gallivan, A.;Pickerell, E.;Hancock, J.;Watkinson, J.;Ryder, B.;Jones, S.;Burbridge, W.;Kitchen, M.;Leary, H. O.;Verow, C.;Meynell, L.;Rollinson, L.;Bain, S.;Jones, A.;Jewkes, C.;Russon, C.;Bateson, M.;Gill, P.;Nicol, J.;Bayly, G.;Stansbie, D.;Andrews, G.;Halestrap, M.;Meredith, J.;Best, R.;Appleyard, D.;Briggs, R.;Wareing, H.;Holmes, K.;Holt, J.;Kenyon, M.;White, C.;Khalifa, M.;Newton, D.;Wass, A.;Watkinson, R.;Creamer, J.;Anderson, S.;Bethell, A.;Butler, C.;Castro, K.;Washington, M.;Weston, M.;Cleaver, K.;Machin, J.;Wray, R.;Sinclair, J.;Van Aalst, A.;Been, M.;Mattu, R.;Bates, D.;Burke, A.;Gill, L.;Walton, E.;Cowley, M.;Robson, H.;Graham, A.;Rose, G.;Kerr, M.;Mallinson, J.;Peascod, B.;Donnelly, R.;Kalk, J.;Scott, A.;Gibson, T.;Hannah, J.;Henshaw, L.;Margetts, M.;Pearson, N.;Frost, S.;Murray, S.;Marshall, A.;Went, J.;Inman, A.;Simmonds, J.;Teasdale, A.;Kemp, T.;Roberts, G.;Kooner, J.;Cahill, S.;Lloyd, M.;Molloy, O.;Wigley, J.;Galvin, M.;Wilder, C.;Lindley, R.;Shaw, S.;Swainson, C.;Hillis, L.;Johnston, J.;Johnstone, A.;Miller, D.;Kennedy, M.;Mushahwar, S.;Savage, M.;Appleyard, D.;Ayer, G.;Schofield, J.;Greenhalgh, S.;Parks, J.;Speak, S.;Coulson, C.;Papouchado, M.;Carpenter, R.;Wisby, J.;Cobbe, S.;Campbell, C.;Hunter, J.;Young, H.;Gallacher, M.;Lindsay, D.;Halliday, A.;Godfrey, S.;Donahoo, L. O.;Chambers, J.;Wierzbicki, A.;Jones, A.;Parkin, D.;Nwafor, K.;Oldroyd, K.;Vallance, B.;Cunningham, N.;Moreland, G.;Oldroyd, C.;Young, H.;Crawford, M.;Hillson, R.;Knott, K.;Mahabir, N.;Crouch, A.;MacDonald, Y.;Bellamy, C.;Green, J.;Brown, L.;Heron, J.;Jones, N.;Roberts, M.;Hainsworth, D.;Williams, J.;Barnes, P.;Fitchet, A.;Longworth, C.;Davidson, J.;Irvine, N.;Oliver, R.;Pond, C.;Nuttall, M.;Mostyn, R. Lloyd;Brown, M.;Barrowcliffe, J.;Blackburn, S.;Furnell, W.;Webster, S.;Wheatley, L.;Hudson, I.;Pohl, J.;Nicholson, S.;Mallya, S.;Nash, M.;Spruce, J.;Bonner, A.;Leather, J.;Searle, A.;Davies, E.;Egdell, R.;Price, B.;Bennett, A. Taylor;Horton, S.;Cunnington, A.;Giles, P.;Sidaway, J.;Tomlinson, L.;Walton, E.;Hawkins, L.;Long, J.;Murphy, J.;Brennan, G.;Boon, M.;Cassidy, S.;Rodger, C.;Hunter, J.;McNeilly, A.;Moreland, G.;Radcliffe, A.;Farrer, M.;Bluett, J.;Cowell, L.;Farrell, A.;Gilroy, S.;Warren, S.;MacConnell, T.;Burtchaell, S.;Williams, L.;Rylance, P.;Hodgson, A.;Hill, K. Kertland;Robinson, L.;Smallwood, A.;Lomas, S.;Ball, J.;Benbow, S.;Hardy, K.;Gerrard, M.;Langley, C.;Beattie, M.;Fagan, C.;Green, B.;Pringle, T.;Hanna, H.;Mackintosh, A.;Watson, E.;Swan, J.;Appleyard, D.;McSorland, D.;Thompson, G.;Neill, C. O.;Curless, R.;Doig, C.;McKenna, P.;Martin, J.;Murdy, J.;Scott, A.;Martin, S.;Birkhead, J.;Donnell, J. O.;Fox, C.;Dixon, S.;Hassall, A.;Tanqueray, E.;Vass, D.;Cosford, I.;Elderkin, M.;McKenzie, P.;Gray, T.;Appleyard, D.;Holmshaw, N.;McKinnon, A.;Bennett, A. Taylor;Ali, I.;Stephens, N.;Banfield, A.;Chester, L.;Wiseman, J.;Harrisingh, N.;Patel, R.;Thaker, P.;Armitage, J.;Watkins, H.;Beebe, S.;Fitzgerald, J.;Godden, J.;Lawson, A.;Lochhead, H.;Taylor, A.;Turner, S.;Rowlands, D.;Cooper, A.;Graham, J.;Hennessy, S.;Rashid, T.;Smith, C.;Nyman, C.;Adams, J.;Hardwick, A.;Buck, P.;Pattinson, C.;Trigg, J.;McLeod, A.;Gardner, S.;Haimes, L.;Orr, S.;Johns, S.;Capps, N.;Cook, A.;Donaldson, D.;Keighley, C.;Stiles, C.;Asbridge, S.;Buller, N.;Townend, J.;Hooks, J.;Jewkes, C.;Jones, H.;Watson, R.;Salt, P.;Francis, M.;MacLeod, D.;Allcoat, P.;Stuart, R.;Reynolds, T.;Maiden, J.;Reynolds, J.;Murray, D.;MacFadyen, R.;Potts, L.;Smith, A.;King, L.;Muthusamy, R.;Jones, M.;Lawan, M.;Nixon, J.;Wasnidge, L.;Weston, C.;Hutchesson, A.;Evans, J.;Morris, K.;Oultram, M.;Armitage, M.;Skule, R.;Cope, C.;Page, M.;Fleming, S.;Andain, K.;Parrett, M.;Soper, R.;MacLeod, K.;Gordon, K.;Green, E.;Havill, S.;Stewart, V.;Allen, S.;Henson, S.;Rimmer, C.;Davies, J.;Javed, M.;Norris, A.;Williams, M.;Khan, S.;Dobie, G.;Fitton, J.;Gilbert, S.;Davenport, C.;Williamson, M.;Vincent, R.;Joyce, E.;Reckless, J.;Bishop, A.;Brice, L.;Carpenter, R.;Field, P.;Shute, C.;Pope, S.;Stacey, D.;Findlay, I.;Campbell, C.;Hunter, J.;Gallacher, M.;Labib, M.;Hodgson, A.;Sidaway, J.;Beddoe, L.;Reed, J.;Barron, J.;Odemuyiwa, O.;Bradford, B.;McDonnell, M.;West, L.;Beck, P.;Gilbey, S.;Clarkson, A.;Drury, K.;Hall, S.;Quartey, D.;Whittam, B.;Lund, D.;Stott, L.;Griffiths, H.;Appleyard, D.;Fitzgerald, J.;Kudarenko, A.;Watkins, J.;Golledge, S.;Pottle, J.;Little, S.;Paine, B.;Shears, C.;Baxter, M.;Wilkinson, P.;Chambers, R.;Hamper, C.;Hollister, E.;Ramsay, H.;Barber, J.;Hopkins, T.;Hughes, L.;Whittaker, J. Elson;Verow, C.;Burke, R. Lambley;Lloyd, C.;Dhawan, J.;John, J.;Bramley, D.;Catchpole, A.;Colecchia, A.;Gray, C.;LeQuelenec, M.;Remington, D.;Wiseman, J.;Gray, C.;Anderson, P.;Woolass, R.;Thomas, P.;Weston, C.;Guy, F.;Lynch, J.;Thomas, R.;Coates, S.;Gait, M.;Waller, D.;Elkins, K.;Franklin, M.;Moore, L.;Signy, M.;Chilton, R.;Joyce, E.;Wrapson, C.;Wiltshire, C.;Lewis, P.;Curtis, J.;Toole, J. O.;Scanlon, S.;Carey, C.;Dobson, L.;Gould, M.;Mansfield, H.;Ranson, G.;Rodaway, M.;Germon, J.;Cockcroft, J.;McDowell, I.;Field, R.;Whiting, J.;Dennison, C.;Roberts, D.;Cooper, M.;Davies, C.;Fitton, J.;Hutt, L.;Radford, L.;Ward, L.;Williamson, M.;McAlpine, H.;Dougall, H.;Robertson, L.;Scott, L.;Young, H.;Humphrey, P.;Saminaden, S.;Watling, D.;Davies, J.;Owen, L.;Clements, M.;Walker, E.;Atkins, E.;Lindley, R.;Shaw, T.;Swainson, C.;Webb, D.;MacCallum, H.;Markie, D.;Melville, V.;Adamson, L.;Johnston, A.;Polukord, E.;Rudden, M.;Hogan, J.;Lie, F.;Badger, V.;Duffy, S.;Mitchell, C.;MacQueen, E.;Baxter, R.;Campbell, S.;McDonald, L.;Wood, H.;Munro, A.;Pycock, C.;Cadwell, J.;Doughty, A.;Harvey, M.;Price, S.;Aldersley, M.;Lock, S.;Pendrey, P.;Barton, J.;Bray, C.;Dayanandan, R.;Wmcott, E.;Achiri, P.;Anderson, C.;Benham, J.;Bojowsky, H.;Boller, I.;Booker, V.;Brewer, A.;Brindley, G.;Cobb, L.;Collett, A.;Corbett, M.;Crowther, J.;Pour, S. Danesh;Edmunds, K.;Fortun, A.;Grimsey, T.;Harwood, C.;Hope, C.;Jones, R.;Jones, S.;Kidney, K.;King, M.;Knight, S.;Lang, H.;Madgwick, Z.;Marsden, C.;Matthews, C.;Matthewson, M.;Miller, J.;Moss, B.;Mostefai, Y.;Murphy, K.;Naughten, A.;Pickworth, S.;Radley, A.;Southren, S.;Sutherland, S.;Tong, R.;Turakani, M.;Umbrath, M.;Armitage, J.;Baigent, C.;Bowman, L.;Bulbulia, R.;Chen, Z.;Clarke, R.;Collins, R.;Dunachie, S.;Dasgupta, T.;Haynes, R.;Landray, M.;Mafham, M.;Majoni, W.;Murray, C.;Naessens, K.;Porter, T.;Rahimi, K.;Reith, C.;Clarke, M. Taylor;Turnbull, C.;Walter, K.;Harding, P.;Lay, M.;Wallendszus, K.;Berry, C.;Bettesworth, H.;Booth, J.;Bowes, M.;Bu, Y.;Charles, A.;Cody, A.;Cox, J.;Emberson, J.;Goodwin, N.;Hurt, C.;Link, E.;McCabe, P.;Munday, A.;Murawska, A.;Offer, A.;Palmer, A.;Parish, S.;Peto, R.;Prajapati, N.;Tochlin, S.;Young, A.;Young, A.;Clark, S.;Kourelhas, K.;Radley, M.;Ambrose, V.;Bradley, M.;Bush, E.;Chavagnon, T.;Chukwurah, B.;Crowley, S.;Dunseath, J.;Emmens, K.;Fletcher, L.;Gordon, J.;Gordon, A.;Hickman, C.;Hill, J.;Ji, M.;Lee, A.;Luker, N.;Norris, S.;Priestley, H.;Sullivan, J.;Taylor, J.;Wintour, J.;Yeung, M.;Youngman, L.;Beebe, S.;Fitzgerald, J.;Godden, J.;Haimes, L.;Lawson, A.;Lochhead, H.;McDonnell, M.;Nash, M.;Taylor, A.;Bennett, A. Taylor;Walton, E.
通讯作者:
Walton, E.
DOI:
10.3390/ph15121474
发表时间:
2022-11-26
期刊:
Pharmaceuticals (Basel, Switzerland)
影响因子:
--
作者:
通讯作者:
--
DOI:
10.1097/coc.0000000000000433
发表时间:
2018-11
期刊:
American journal of clinical oncology
影响因子:
--
作者:
Iarrobino NA;Gill B;Bernard ME;Mishra MV;Champ CE
通讯作者:
Champ CE
DOI:
10.1007/s10552-021-01450-0
发表时间:
2021-09
期刊:
Cancer causes & control : CCC
影响因子:
--
作者:
Lopez DS;Huang D;Tsilidis KK;Canfield S;Khera M;Baillargeon JG;Kuo YF;Peek MK;Platz EA;Markides K
通讯作者:
Markides K