Silver or nitrofurazone impregnation of urinary catheters has a minimal effect on uropathogen adherence.
Silver or nitrofurazone impregnation of urinary catheters has a minimal effect on uropathogen adherence.
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DOI：
10.1016/j.juro.2010.07.036
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Trautner BW
中科院分区：
文献类型：
--
作者：
Desai DG;Liao KS;Cevallos ME;Trautner BW
细菌粘附于导尿管是生物膜形成的早期步骤，也是导尿管相关性尿路感染的发病机制。我们在体外研究了银或呋喃西林浸渍导尿管对尿路病原体粘附导尿管能力的影响。我们研究了市售的呋喃酮-硅胶、仅硅胶、银-硅胶-水凝胶、硅胶-水凝胶、银-乳胶-水凝胶和乳胶-水凝胶导管。将导管分别在无菌肉汤中孵育0、3、5、7和10天，然后接种并与大肠杆菌或粪肠球菌过夜孵育。E. coli和E.当导管是新鲜的时，与仅含硅胶的导管相比，faecalis对呋喃西林导管的耐受性显著降低。观察了呋喃西林对E.大肠埃希菌随时间下降，但在第5天仍显着。大肠faecalis，通过3天的预孵育，呋喃西林的作用丧失。e.与相同基材的对照导管相比，银浸渍导管上的大肠杆菌粘附没有显著降低。银与E.粪便粘附乳胶-水凝胶导管，但不粘附硅胶-水凝胶导管。各物种对含水凝胶的硅胶导管的粘附性显著低于仅含硅胶的对照导管。在我们的模型中，银浸渍对细菌粘附几乎没有影响，而硝唑浸渍仅在前5天有显着影响。我们的研究结果不支持银导尿管通过减少细菌粘附来预防导管相关尿路感染的作用。
Bacterial adherence to the urinary catheter is an early step in biofilm formation and the pathogenesis of catheter associated urinary tract infection. We studied in vitro the effect of silver or nitrofurazone impregnation of urinary catheters on uropathogen ability to adhere to urinary catheters. We studied commercially available nitrofurazone-silicone, silicone only, silver-silicone-hydrogel, silicone-hydrogel, silver-latex-hydrogel and latex-hydrogel catheters. Catheters were incubated in sterile broth for 0, 3, 5, 7 and 10 days, respectively, before inoculation and overnight incubation with Escherichia coli or Enterococcus faecalis. Adherence of E. coli and E. faecalis to nitrofurazone catheters was significantly decreased compared to that of silicone-only catheters when catheters were fresh. The anti-adherence effect of nitrofurazone on E. coli decreased with time but was still significant at 5 days. For E. faecalis the effect of nitrofurazone was lost by 3 days of pre-incubation. E. coli adherence was not significantly decreased on silver impregnated catheters compared to that on control catheters of the same base material. Silver was associated with a significant decrease in E. faecalis adherence to latex-hydrogel catheters but not to silicone-hydrogel catheters. The adherence of each species to silicone catheters with hydrogel was significantly lower than that to silicone-only control catheters. Silver impregnation had little effect on bacterial adherence in our model and nitrofurazone impregnation had a significant effect only for the first 5 days. Our results do not support a role for silver urinary catheters to prevent catheter associated urinary tract infection by decreasing bacterial adherence.
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影响因子：
2.1
作者：
Trautner, BW;Hull, RA;Darouiche, RO
通讯作者：
Darouiche, RO
影响因子：
6.9
作者：
Stickler, D. J.;Morgan, S. D.
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Morgan, S. D.
影响因子：
3.2
作者：
CHANG, ACY;COHEN, SN
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COHEN, SN
影响因子：
2.6
作者：
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影响因子：
6.6
作者：
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通讯作者：
Thornby, JI