X-ray crystal structure of the passenger domain of plasmid encoded toxin(Pet), an autotransporter enterotoxin from enteroaggregative Escherichia coli (EAEC).
X-ray crystal structure of the passenger domain of plasmid encoded toxin(Pet), an autotransporter enterotoxin from enteroaggregative Escherichia coli (EAEC).
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DOI：
10.1016/j.bbrc.2014.02.016
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发表时间：
2014-03-07
影响因子：
3.1
通讯作者：
Fromme, Raimund
中科院分区：
文献类型：
--
作者：
Domingo Meza-Aguilar, J.;Fromme, Petra;Torres-Larios, Alfredo;Mendoza-Hernandez, Guillermo;Hernandez-Chinas, Ulises;Arreguin-Espinosa de los Monteros, Roberto A.;Eslava Campos, Carlos A.;Fromme, Raimund
Autotransporters (ATs) represent a superfamily of proteins produced by a variety of pathogenic bacteria, which include the pathogenic groups of Escherichia coli (E. coli) associated with gastrointestinal and urinary tract infections. We present the first X-ray structure of the passenger domain from the Plasmid-encoded toxin (Pet) a 100 kDa protein at 2.3 Å resolution which is a cause of acute diarrhea in both developing and industrialized countries. Pet is a cytoskeleton-altering toxin that induces loss of actin stress fibers. While Pet (pdb code: 4OM9) shows only a sequence identity of 50 % compared to the closest related protein sequence, extracellular serine protease plasmid (EspP) the structural features of both proteins are conserved. A closer structural look reveals that Pet contains a β-pleaded sheet at the sequence region of residues 181-190, the corresponding structural domain in EspP consists of a coiled loop. Secondary, the Pet passenger domain features a more pronounced beta sheet between residues 135-143 compared to the structure of EspP.
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影响因子：
5.7
作者：
Brunger, Axel T.;Adams, Paul D.;Fromme, Petra;Fromme, Raimund;Levitt, Michael;Schroeder, Gunnar F.
通讯作者：
Schroeder, Gunnar F.
影响因子：
48
作者：
Chayen, Naomi E.;Saridakis, Emmanuel
通讯作者：
Saridakis, Emmanuel
影响因子：
3.1
作者：
Leyton, DL;Sloan, J;Hartland, EL
通讯作者：
Hartland, EL
DOI：
10.1107/s0907444909052925
发表时间：
2010-02
期刊：
Acta crystallographica. Section D, Biological crystallography
影响因子：
--
作者：
Adams PD;Afonine PV;Bunkóczi G;Chen VB;Davis IW;Echols N;Headd JJ;Hung LW;Kapral GJ;Grosse-Kunstleve RW;McCoy AJ;Moriarty NW;Oeffner R;Read RJ;Richardson DC;Richardson JS;Terwilliger TC;Zwart PH
通讯作者：
Zwart PH
影响因子：
5.6
作者：
Khan, Shekeb;Mian, Hira S.;Sandercock, Linda E.;Chirgadze, Nickolay Y.;Pai, Emil F.
通讯作者：
Pai, Emil F.