Rheological characterization of cellular blood in shear
Rheological characterization of cellular blood in shear
复制标题
剪切下细胞血液的流变学特征
DOI：
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发表时间：
2013
影响因子：
3.7
通讯作者：
C. Aidun
中科院分区：
文献类型：
--
作者：
D. Reasor;J. Clausen;C. Aidun
摘要采用混合格子-玻耳兹曼光谱链(LB-SL)方法模拟红细胞的致密悬浮液，研究血液的流变性。用粗粒SL方法模拟红细胞膜，并填充粘度为悬浮液五倍的粘性牛顿流体溶液。相对粘度、正常应力差和颗粒压力是在生理上实际的红细胞压积大约为42.5%时的毛细管数范围内报告的。在剪切速率为14~440的S−-1范围内，表现出粘性剪切稀化现象，并且受到红细胞取向和弯曲模数的影响。随着剪切速率的增加，颗粒相压力经历由正到负的符号变化。颗粒相法向应力张量值表明，随着剪切速率的增加，流动方向上存在从压缩状态到拉伸状态的转变。法向应力差异与最近报道的可变形胶囊悬浮液的应力差异显著不同，这表明红细胞的弯曲刚度和双凹形状影响血液的流变学。
Abstract A hybrid lattice-Boltzmann spectrin-link (LB–SL) method is used to simulate dense suspensions of red blood cells (RBCs) for investigating rheological properties of blood. RBC membranes are modelled using a coarse-grained SL method and are filled with a viscous Newtonian fluid solution with viscosity five times that of the suspending fluid. Relative viscosities, normal stress differences, and particle pressures are reported for a range of capillary numbers at a physiologically realistic haematocrit value of approximately 42.5 %. Viscosity shear thinning is demonstrated for shear rates ranging from 14 to 440 s−1 and is shown to be affected by the orientation and bending modulus of RBCs. The particle-phase pressure undergoes a change in sign from positive to negative as the shear rate is increased. The particle-phase normal stress tensor values show that there is a transition from compressive to tensile states in the flow direction as the shear rate is increased. The normal stress differences are notably different from those recently reported for deformable capsule suspensions using a similar methodology, which suggests that the bending stiffness and the biconcave shape of RBCs affect the rheology of blood.
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DOI：
10.1016/j.cma.2010.02.001
发表时间：
2010-06-01
影响因子：
7.2
作者：
Fedosov DA;Caswell B;Karniadakis GE
通讯作者：
Karniadakis GE
影响因子：
3.4
作者：
Fedosov, Dmitry A.;Caswell, Bruce;Karniadakis, George Em
通讯作者：
Karniadakis, George Em
影响因子：
2.4
作者：
Dupin, Michael M.;Halliday, Ian;Munn, Lance L.
通讯作者：
Munn, Lance L.
影响因子：
3.4
作者：
Hwang, WC;Waugh, RE
通讯作者：
Waugh, RE