Optical coherence tomography for advanced screening in the primary care office.
Optical coherence tomography for advanced screening in the primary care office.
复制标题
光学相干断层扫描，用于初级保健办公室的高级筛查。
DOI：
10.1002/jbio.201200243
复制
发表时间：
2014-07
影响因子：
2.8
通讯作者：
Boppart, Stephen A.
中科院分区：
文献类型：
--
作者：
Shelton, Ryan L.;Jung, Woonggyu;Sayegh, Samir I.;McCormick, Daniel T.;Kim, Jeehyun;Boppart, Stephen A.
光学相干层析成像(OCT)长期以来一直被用作眼科领域的诊断工具。事实证明，观察眼睛组织微结构变化的能力在诊断眼病方面非常有效。然而，这项技术尚未被引入初级保健办公室，在那里第一次遇到疾病的迹象。我们已经开发了一种用于初级保健环境的便携式手持成像探头，并评估了其组织部位的可访问性、观察病变组织的能力以及对活体人类患者的筛查能力，特别是与眼、耳和皮肤相关的病理。使用手持探头观察糖尿病视网膜病变的不同阶段，并从OCT图像中标记出早期糖尿病视网膜病变为异常。在疾病的早期阶段，用目前初级保健医生可用的有限工具很难观察到异常。这些结果表明，OCT有望从内科和外科专科的诊断技术转变为初级保健办公室和医疗保健一线的筛查技术。初级保健医生遇到的人类常见病理的四个例子的横断面图像。所有的图像都是使用一种新型的手持OCT成像探头拍摄的。(A)准分子激光原位角膜磨镶术后的人体角膜。(B)晚期糖尿病视网膜病变。(C)鼓膜伴生生物膜。(D)皮肤脓肿表现为分层分离和充满液体的口袋。
Optical coherence tomography (OCT) has long been used as a diagnostic tool in the field of ophthalmology. The ability to observe microstructural changes in the tissues of the eye has proved very effective in diagnosing ocular disease. However, this technology has yet to be introduced into the primary care office, where indications of disease are first encountered. We have developed a portable, handheld imaging probe for use in the primary care setting and evaluated its tissue site accessibility, ability to observe diseased tissue, and screening capabilities in in vivo human patients, particularly for pathologies related to the eye, ear and skin. Various stages of diabetic retinopathy were investigated using the handheld probe and early-stage diabetic retinopathy was flagged as abnormal from the OCT images. At such early stages of disease, it is difficult to observe abnormalities with the limited tools that are currently available to primary care physicians. These results indicate that OCT shows promise to transform from being a diagnostic technology in the medical and surgical specialities to a screening technology in the primary care office and at the front-line of healthcare. cross-sectional images of four examples of common pathologies in humans encountered by a primary care physician. All images were taken using a novel handheld OCT imaging probe. (A) Human cornea after LASIK surgery. (B) Advanced diabetic retinopathy. (C) Tympanic membrane with accompanying biofilm. (D) Skin abscess showing layer separation and fluid-filled pockets.
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DOI：
10.1109/memb.2009.935722
发表时间：
2010-03
期刊：
IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society
影响因子：
--
作者：
Nguyen FT;Zysk AM;Chaney EJ;Adie SG;Kotynek JG;Oliphant UJ;Bellafiore FJ;Rowland KM;Johnson PA;Boppart SA
通讯作者：
Boppart SA
DOI：
10.1016/s1052-5157(03)00012-6
发表时间：
2003-04-01
影响因子：
--
作者：
Poneros, John M;Nishioka, Norman S
通讯作者：
Nishioka, Norman S
DOI：
10.1073/pnas.1201592109
发表时间：
2012-06-12
影响因子：
11.1
作者：
Nguyen, Cac T.;Jung, Woonggyu;Boppart, Stephen A.
通讯作者：
Boppart, Stephen A.
影响因子：
3.8
作者：
Gao SS;Xia A;Yuan T;Raphael PD;Shelton RL;Applegate BE;Oghalai JS
通讯作者：
Oghalai JS
DOI：
10.1097/mao.0b013e3181e711b8
发表时间：
2010-08
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Djalilian HR;Rubinstein M;Wu EC;Naemi K;Zardouz S;Karimi K;Wong BJ
通讯作者：
Wong BJ