Optical coherence tomography of cholesteatoma.
Optical coherence tomography of cholesteatoma.
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DOI：
10.1097/mao.0b013e3181e711b8
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Wong BJ
中科院分区：
文献类型：
--
作者：
Djalilian HR;Rubinstein M;Wu EC;Naemi K;Zardouz S;Karimi K;Wong BJ
使用光学相干断层扫描 (OCT) 对胆脂瘤进行成像，并将结果与临床发现以及使用双目显微镜和组织学获得的常规观察结果相关联。 OCT 是一种高分辨率光学成像方式，可生成混浊介质（例如分辨率接近光学显微镜的组织）的横截面图像。 OCT 依靠组织光学特性的内在差异来实现图像对比度。体内前瞻性临床研究。大学医学中心。接受耳科手术的胆脂瘤患者。使用商用 OCT 成像系统，我们获得了胆脂瘤的横截面图像（分辨率，~10 μm；深度穿透，~1 mm）。通过对探头内部的单模光纤进行光栅扫描来获得图像。将成像探头消毒并在显微镜引导下插入中耳或乳突，获得中耳或乳突粘膜和胆脂瘤存在时的静态图像。胆脂瘤的 OCT 图像显示出信号强度的差异，这与正常或发炎的中耳/乳突粘膜的信号强度不同。胆脂瘤中角蛋白的鉴定，即使非常薄，也可以将其与发炎的粘膜区分开来。这是第一项在耳科手术期间系统地使用 OCT 对胆脂瘤进行成像的研究。胆脂瘤可以与正常或发炎的邻近粘膜区分开来。
To image cholesteatoma using optical coherence tomography (OCT) and correlate the results with clinical findings and conventional observations obtained using binocular microscopy and histology. OCT is a high-resolution optical imaging modality that generates cross-sectional images of turbid media, such as tissue with resolution approaching that of light microscopy. OCT relies on intrinsic differences in tissue optical properties for image contrast. In vivo prospective clinical study. University Medical Center. Patients with cholesteatoma undergoing otologic surgery. Using a commercial OCT imaging system, we obtained cross-sectional images (resolution, ~10 μm; depth penetration, ~1 mm) of cholesteatomas. Images are obtained by raster scanning a single mode fiber across the interior of the probe. The imaging probe is sterilized and inserted into the middle ear or mastoid under microscopic guidance, and still images of the middle ear or mastoid mucosa and cholesteatoma when present were obtained. OCT images of cholesteatomas demonstrate differences in signal intensity, which are distinct from those of normal or inflamed middle ear/mastoid mucosa. Identification of keratin in cholesteatoma, even if very thin, distinguished it from inflamed mucosa. This is the first study that systematically used OCT to image cholesteatoma during otologic surgery. Cholesteatomas can be distinguished from normal or inflamed adjacent mucosa.
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DOI：
10.1097/mao.0b013e31818a08ce
发表时间：
2008-12
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Djalilian HR;Ridgway J;Tam M;Sepehr A;Chen Z;Wong BJ
通讯作者：
Wong BJ
影响因子：
2.6
作者：
Ridgway, James Matthew;Ahuja, Gurpreet;Wong, Brian
通讯作者：
Wong, Brian
影响因子：
3.4
作者：
Sepehr, Ali;Armstrong, William B.;Wong, Brian J. F.
通讯作者：
Wong, Brian J. F.
影响因子：
2.6
作者：
Armstrong, William B.;Ridgway, James M.;Wong, Brian J. F.
通讯作者：
Wong, Brian J. F.
影响因子：
2.6
作者：
Wong, BJF;Jackson, RP;Chen, ZP
通讯作者：
Chen, ZP