Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study.
Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study.
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DOI：
10.1038/ijo.2008.280
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发表时间：
2009-03
影响因子：
4.9
通讯作者：
Ribisl, P. M.
中科院分区：
文献类型：
--
作者：
Jakicic, J. M.;Jaramillo, S. A.;Balasubramanyam, A.;Bancroft, B.;Curtis, J. M.;Mathews, A.;Pereira, M.;Regensteiner, J. G.;Ribisl, P. M.
在Look AHEAD试验中，研究强化生活方式减肥干预（ILI）与糖尿病支持和教育（DSE）相比对健康和体力活动变化的影响。比较生活方式干预与糖尿病支持和教育条件对2型糖尿病患者减肥效果的随机临床试验分析了来自4，376名超重或肥胖的2型糖尿病成年人（年龄= 58.7±6.8岁，BMI = 35.8±5.8 kg/m2）的数据，这些人完成了为期一年的Look AHEAD试验，并有可用的健身数据。受试者被随机分配至DSE或ILI组。DSE在一年期间接受标准护理加3次教育课程。ILI包括全年的个人和团体接触，限制能量摄入，以及175分钟/周的规定体力活动。使用次极量分级运动试验评估体能。通过问卷对2,221名受试者的身体活动进行了评估。调整基线适应性后，ILI组的适应性变化在统计学上大于DSE组（20.9% vs. 5.7%）（p<0.0001）。多变量分析显示，超重与肥胖II级和III级相比，健身的变化更大（p<0.05）。ILI组体力活动增加892±1694 kcal/wk，DSE组增加108±1254 kcal/wk（p<0.01）。健身（r=0.41）和体力活动（r=0.42）的变化与体重减轻显著相关（p<0.0001）。ILI在增加体力活动和改善超重和肥胖2型糖尿病患者的心肺功能方面有效。这种效果可能会增加体重减轻，改善生活方式干预计划中患者的代谢控制。
To examine the effect of an intensive lifestyle weight loss intervention (ILI) compared to diabetes support and education (DSE) on changes in fitness and physical activity in the Look AHEAD trial. Randomized clinical trial to compare a lifestyle intervention for weight loss with a diabetes support and education condition in individuals with type 2 diabetes. Data from 4,376 overweight or obese adults with type 2 diabetes (age = 58.7±6.8 years, BMI = 35.8±5.8 kg/m2) who completed one-year of the Look AHEAD trial and had available fitness data were analyzed. Subjects were randomly assigned to DSE or ILI. DSE received standard-care plus 3 education sessions over the one-year period. ILI included individual and group contact throughout the year, restriction in energy intake, and 175 min/wk of prescribed physical activity. Fitness was assessed using a submaximal graded exercise test. Physical activity was assessed via questionnaire in a subset of 2,221 subjects. Change in fitness was statistically greater in ILI vs. DSE after adjustment for baseline fitness (20.9% vs. 5.7%) (p<0.0001). Multivariate analysis showed that change in fitness was greater in overweight vs. obese Class II and III (p<0.05). Physical activity increased by 892±1694 kcal/wk in ILI vs. 108±1254 kcal/wk in DSE (p<0.01). Changes in fitness (r=0.41) and physical activity (r=0.42) were significantly correlated with weight loss (p<0.0001). The ILI was effective in increasing physical activity and improving cardiorespiratory fitness in overweight and obese individuals with type 2 diabetes. This effect may add to weight loss in improving metabolic control in patients in lifestyle intervention programs.
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影响因子：
8.2
作者：
Eriksen, L.;Dahl-Petersen, I.;Dela, F.
通讯作者：
Dela, F.
女性体重指数、心肺功能与全因死亡率的关系
DOI：
10.1038/oby.2002.58
发表时间：
2002-06-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Farrell, SW;Braun, L;Blair, SN
通讯作者：
Blair, SN
影响因子：
8.2
作者：
Middlebrooke, A. R.;Elston, L. M.;Tooke, J. E.
通讯作者：
Tooke, J. E.
超重和肥胖 2 型糖尿病患者的运动能力和心血管/代谢特征 - Look AHEAD 临床试验
影响因子：
16.2
作者：
Ribisl, Paul M.;Lang, Wei;Soberman, Judith E.
通讯作者：
Soberman, Judith E.
影响因子：
16.2
作者：
Lee, S;Kuk, JL;Ross, R
通讯作者：
Ross, R