Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania.
Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania.
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DOI：
10.1038/s41598-022-15517-8
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发表时间：
2022-07-08
影响因子：
4.6
通讯作者：
Allan, Kathryn J.
中科院分区：
文献类型：
--
作者：
Thomas, Kate M.;Kibona, Tito;Claxton, John R.;de Glanville, William A.;Lankester, Felix;Amani, Nelson;Buza, Joram J.;Carter, Ryan W.;Chapman, Gail E.;Crump, John A.;Dagleish, Mark P.;Halliday, Jo E. B.;Hamilton, Clare M.;Innes, Elisabeth A.;Katzer, Frank;Livingstone, Morag;Longbottom, David;Millins, Caroline;Mmbaga, Blandina T.;Mosha, Victor;Nyarobi, James;Nyasebwa, Obed M.;Russell, George C.;Sanka, Paul N.;Semango, George;Wheelhouse, Nick;Willett, Brian J.;Cleaveland, Sarah;Allan, Kathryn J.
牲畜流产是全世界生产力损失的一个重要原因，流产的许多传染性原因是影响人类健康的人畜共患病原体。在非洲，包括严重依赖牲畜获取食物、收入和福祉的自给农业社区，人们对牲畜流产的传染原因的相对重要性知之甚少。在横断面血清监测的支持下，我们进行了一项牲畜流产的前瞻性队列研究，以确定坦桑尼亚牲畜流产的病因。这一方法产生了若干重要发现，包括在牛中发现裂谷热病毒暴发；牲畜中伯纳蒂菌感染率高；以及坦桑尼亚首次报告与牲畜流产有关的犬新孢子虫、刚地弓形虫和鼠疫病毒。我们的方法为资源有限的环境下的堕胎监测提供了一个模型。我们的发现大大增加了撒哈拉以南非洲目前的知识，为确定疾病干预措施的优先次序提供了重要证据。
Livestock abortion is an important cause of productivity losses worldwide and many infectious causes of abortion are zoonotic pathogens that impact on human health. Little is known about the relative importance of infectious causes of livestock abortion in Africa, including in subsistence farming communities that are critically dependent on livestock for food, income, and wellbeing. We conducted a prospective cohort study of livestock abortion, supported by cross-sectional serosurveillance, to determine aetiologies of livestock abortions in livestock in Tanzania. This approach generated several important findings including detection of a Rift Valley fever virus outbreak in cattle; high prevalence of C. burnetii infection in livestock; and the first report of Neospora caninum, Toxoplasma gondii, and pestiviruses associated with livestock abortion in Tanzania. Our approach provides a model for abortion surveillance in resource-limited settings. Our findings add substantially to current knowledge in sub-Saharan Africa, providing important evidence from which to prioritise disease interventions.
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