A major allogenic leukocyte antigen in the agnathan hagfish.
A major allogenic leukocyte antigen in the agnathan hagfish.
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DOI：
10.1038/srep01716
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发表时间：
2013
影响因子：
4.6
通讯作者：
Sakano, Hitoshi
中科院分区：
文献类型：
--
作者：
Takaba, Hiroyuki;Imai, Takeshi;Miki, Shoji;Morishita, Yasuyuki;Miyashita, Akihiro;Ishikawa, Naoko;Nishizumi, Hirofumi;Sakano, Hitoshi
所有的脊椎动物，从无颌鱼到哺乳动物，都具有适应性免疫系统，可以通过大量的抗原受体来检测和识别非自身抗原。与有颌脊椎动物不同，盲鳗利用与免疫球蛋白分子无关但通过拷贝选择基因转换机制多样化的可变淋巴细胞受体（VLRs）。在这里，我们报告说，盲鳗VLRs反应与同种异体白细胞抗原，但不与自身抗原。我们发现，一个高度多态性的膜蛋白，NICIR 3，被VLRs识别为同种异体白细胞抗原（ALA）。在血清学交叉反应性试验中，观察到蛋白质序列中的氨基酸差异与VLR交叉反应性之间存在密切相关性。这种白细胞抗原主要在吞噬性白细胞中表达，在那里它与吞噬蛋白抗原相关。这些发现表明，多态性白细胞抗原，NICIR 3/ALA，在无颌脊椎动物的适应性免疫中起着关键作用。
All vertebrates, from jawless fish to mammals, possess adaptive immune systems that can detect and inactivate non-self-antigens through a vast repertoire of antigen receptors. Unlike jawed vertebrates, the hagfish utilizes variable lymphocyte receptors (VLRs) that are unrelated to immunoglobulin molecules but are diversified by copy-choice gene conversion mechanism. Here, we report that hagfish VLRs react with allogenic leukocyte antigens but not with self-antigens. We found that a highly polymorphic membrane protein, NICIR3, is recognized by VLRs as an allogenic leukocyte antigen (ALA). In a serological cross-reactivity test, a close correlation was observed between the amino acid differences in the protein sequences and the VLR cross-reactivities. This leukocyte antigen was predominantly expressed in phagocytic leukocytes, where it was associated with phagocytosed protein antigens. These findings suggest that a polymorphic leukocyte antigen, NICIR3/ALA, plays a pivotal role in jawless vertebrate adaptive immunity.
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