Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease.
Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease.
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DOI：
10.1016/j.neuroimage.2010.05.036
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发表时间：
2010-10-01
期刊：
影响因子：
5.7
通讯作者：
Smith, Charles D.
中科院分区：
文献类型：
--
作者：
Gold, Brian T.;Powell, David K.;Andersen, Anders H.;Smith, Charles D.
关键词：
有证据表明，白质(WM)微结构的破坏是阿尔茨海默病(AD)病程中的早期事件。然而，症状前阿尔茨海默病患者WM微结构下降的神经生物学基础尚不清楚。在本研究中，我们使用多模式成像方法来研究症状前AD，以解决这一问题。参与者是37名高危女性(既有痴呆症家族史，也有一个或多个APOE4等位基因)和20名低危女性(既没有家族病史，也没有APOE4)。这些组在年龄、教育程度、神经心理表现和可能影响脑白质的血管因素方面进行了匹配。对弥散张量成像数据进行全脑分析[包括分数各向异性(FA)、平均扩散系数(MD)、轴向扩散系数(DA)和径向扩散系数(DR)]，并对内侧颞叶(MTL)结构进行体积比较。结果表明，风险组之间内嗅皮层和海马体体积相等。然而，高风险组表现出与MTL直接和继发连接的西医间质束微结构完整性降低。在AD高危人群中，WM完整性的主要改变是FA减少，而不是仅由DA或DR的改变驱动，在没有观察到MD改变的区域。在较少区域观察到的第二种模式涉及FA减少和DR增加。这些结果表明，MTL-新皮质纤维通路的断开代表了AD过程中的一个非常早期的事件，并提示脱髓鞘可能是一个促成机制。
There is evidence that disruption of white matter (WM) microstructure is an early event in the course of Alzheimer’s disease (AD). However, the neurobiological bases of WM microstructural declines in presymptomatic AD are unknown. In the present study we address this issue using a multimodal imaging approach to the study of presymptomatic AD. Participants were 37 high risk (both family history of dementia and one or more APOE4 alleles) women and 20 low risk (neither family history nor APOE4) women. Groups were matched for age, education, neuropsychological performance, and vascular factors that could affect white matter. Whole-brain analyses of diffusion tensor imaging data [including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (DA) and radial diffusivity (DR)] and volumetric comparisons of medial temporal lobe (MTL) structures were conducted. Results indicated equivalent entorhinal cortex and hippocampal volumes between risk groups. Nevertheless, the high risk group showed decreased microstructural integrity in WM tracts with direct and secondary connections to the MTL. The predominant alteration in WM integrity in the high AD-risk group was decreased FA not solely driven by either DA or DR changes alone in regions where no MD changes were observed. A second pattern observed in a smaller number of regions involved decreased FA and increased DR. These results suggest that disconnection of MTL-neocortical fiber pathways represents a very early event in the course of AD and suggest that demyelination may represent one contributing mechanism.
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影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
5.7
作者：
Hui, Edward S.;Cheung, Matthew M.;Wu, Ed X.
通讯作者：
Wu, Ed X.
影响因子：
14.5
作者：
ENGLUND, E;BRUN, A;ALLING, C
通讯作者：
ALLING, C
影响因子：
4.2
作者：
Bartzokis G
通讯作者：
Bartzokis G