pH-Sensitive Targeting of Tumors with Chemotherapy-Laden Nanoparticles: Progress and Challenges.
pH-Sensitive Targeting of Tumors with Chemotherapy-Laden Nanoparticles: Progress and Challenges.
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DOI：
10.3390/pharmaceutics14112427
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发表时间：
2022-11-10
期刊：
影响因子：
5.4
通讯作者：
Mixson, A. James
中科院分区：
文献类型：
--
作者：
Imtiyaz, Zuha;He, Jiaxi;Leng, Qixin;Agrawal, Atul K.;Mixson, A. James
在肿瘤内积累化疗药物如阿霉素，同时限制药物剂量到正常组织是用纳米颗粒递送药物的中心目标。脂质体产品如Doxil®代表了基于纳米颗粒的策略的显著成功之一。为了在癌症治疗中复制这一成功，正在探索许多使用纳米颗粒的方法，以引导和释放化疗剂，从而在肿瘤中实现更高的积累。一种有前途的方法是基于刺激的治疗，例如在肿瘤基质或肿瘤内体的酸性环境中从纳米颗粒释放化疗剂。当到达肿瘤的酸性环境时，由pH依赖性聚合物组成的颗粒变得带电并释放捕获的化疗剂。本文综述了pH依赖性组氨酸纳米粒的最新研究进展和应用前景。研究人员使用的策略包括一系列含组氨酸的肽和聚合物，它们形成胶束、混合胶束、纳米囊泡、复合物和包衣颗粒。迄今为止，几种有前途的基于组氨酸的纳米颗粒已被证明能显著抑制肿瘤生长，但在临床试验中取得成功仍面临挑战。从这些含组氨酸的颗粒中吸取的教训将为开发用于化疗的改进的pH依赖性聚合物递送系统提供见解。
Accumulating chemotherapeutic drugs such as doxorubicin within a tumor while limiting the drug dose to normal tissues is a central goal of drug delivery with nanoparticles. Liposomal products such as Doxil® represent one of the marked successes of nanoparticle-based strategies. To replicate this success for cancer treatment, many approaches with nanoparticles are being explored in order to direct and release chemotherapeutic agents to achieve higher accumulation in tumors. A promising approach has been stimulus-based therapy, such as the release of chemotherapeutic agents from the nanoparticles in the acidic environments of the tumor matrix or the tumor endosomes. Upon reaching the acidic environments of the tumor, the particles, which are made up of pH-dependent polymers, become charged and release the entrapped chemotherapy agents. This review discusses recent advances in and prospects for pH-dependent histidine-based nanoparticles that deliver chemotherapeutic agents to tumors. The strategies used by investigators include an array of histidine-containing peptides and polymers which form micelles, mixed micelles, nanovesicles, polyplexes, and coat particles. To date, several promising histidine-based nanoparticles have been demonstrated to produce marked inhibition of tumor growth, but challenges remain for successful outcomes in clinical trials. The lessons learned from these histidine-containing particles will provide insight in the development of improved pH-dependent polymeric delivery systems for chemotherapy.
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影响因子：
5.2
作者：
Chen YC;Chang CJ;Hsiue GH;Chiang YT
通讯作者：
Chiang YT
基于聚甲基丙烯酰胺结构的超灵敏（共）聚合物，具有精细可调的 pH 响应值
DOI：
10.3390/molecules23081870
发表时间：
2018-07-27
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Fan H;Li P;Li W;Li H;Huang X
通讯作者：
Huang X
DOI：
10.1002/advs.202103745
发表时间：
2022-04
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Biancacci I;De Lorenzi F;Theek B;Bai X;May JN;Consolino L;Baues M;Moeckel D;Gremse F;von Stillfried S;El Shafei A;Benderski K;Azadkhah Shalmani A;Wang A;Momoh J;Peña Q;Buhl EM;Buyel J;Hennink W;Kiessling F;Metselaar J;Shi Y;Lammers T
通讯作者：
Lammers T
影响因子：
5
作者：
Alotaibi KM;Almethen AA;Beagan AM;Alfhaid LH;Ahamed M;El-Toni AM;Alswieleh AM
通讯作者：
Alswieleh AM
影响因子：
6.2
作者：
Car, Anja;Baumann, Patric;Meier, Wolfgang
通讯作者：
Meier, Wolfgang