Association of urinary concentrations of phthalate metabolites and bisphenol A with early pregnancy endpoints.
Association of urinary concentrations of phthalate metabolites and bisphenol A with early pregnancy endpoints.
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DOI：
10.1016/j.envres.2018.09.037
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发表时间：
2019-01
影响因子：
8.3
通讯作者：
Baird DD
中科院分区：
文献类型：
--
作者：
Chin HB;Jukic AM;Wilcox AJ;Weinberg CR;Ferguson KK;Calafat AM;McConnaughey DR;Baird DD
邻苯二甲酸酯和双酚A（BPA）是可能影响早期胚胎发育的环境污染物。评估邻苯二甲酸酯代谢物和BPA与怀孕前随访的女性队列中早孕终点之间的相关性。我们在137个自然受孕的临床妊娠周期中定量了11种邻苯二甲酸酯代谢物和BPA。邻苯二甲酸酯代谢物和BPA浓度测定在一个合并的样本，每天早晨三个尿液标本。每日尿激素测量以前被用来确定排卵，植入，黄体抢救。我们评估了妊娠周期暴露（邻苯二甲酸酯生物标志物和BPA）与1）从排卵到着床的时间; 2）黄体挽救类型（孕酮升高的时间和模式：早期，晚期或无升高）; 3）hCG初始升高率之间的关系。邻苯二甲酸单（3-羧丙基）酯（MCPP）和邻苯二甲酸单异丁酯（MiBP）与早期植入相关（6-8天与9天（最常见的观察）;根据自然对数单位，OR（95%CI）= 2.8（1.2，6.7）和OR（CI）= 2.1（1.2，3.7）分别）。邻苯二甲酸单乙酯（MEP）与植入延迟相关（10-12天vs. 9天）; OR（CI）= 1.5（1.0，2.1）。与第9天着床相比，BPA与早期和晚期着床均显著相关（OR=2.2）。浓度高于邻苯二甲酸单苄酯（MBzP）中位数（p=0.04）或高于四种邻苯二甲酸二（2-乙基己基）酯代谢物（∑DEHP）摩尔总和中位数（p=0.08）的女性hCG初始升高较慢。MCPP增加与晚起床急救的几率增加相关（OR（CI）= 2.9（1.0，8.5）;晚起床vs.早起），而MEP增加与无起床急救相关（OR（CI）= 1.6（0.9，2.8）;无起床vs.早起）。所报告的协会在其影响方向上各不相同，一些潜在的保护，其他不利的。这可能反映了这些潜在的内分泌干扰化学品的复杂性，但偶然的发现也是可能的。鉴于妇女继续接触这些化合物（或其前体），有必要继续研究它们对怀孕的影响。
Phthalates and bisphenol A (BPA) are environmental contaminants that may affect early embryonic development. To assess the association between phthalate metabolites and BPA with early pregnancy endpoints in a cohort of women followed from before conception. We quantified 11 phthalate metabolites and BPA in 137 conception cycles from naturally conceived clinical pregnancies. Phthalate metabolites and BPA concentrations were measured in a pooled sample of three daily morning urine specimens. Daily urinary hormone measurements had previously been used to define ovulation, implantation, and corpus luteum rescue. We assessed associations between conception cycle exposures (phthalate biomarkers and BPA) and 1) time from ovulation to implantation; 2) type of corpus luteum rescue (timing and pattern of rise in progesterone: early, late, or no rise); and 3) rate of initial rise in hCG. Mono(3-carboxypropyl) phthalate (MCPP) and mono-isobutyl phthalate (MiBP) were associated with earlier implantation (6–8 days vs. 9 days (the most commonly observed); per natural log-unit, OR (95% CI) = 2.8 (1.2, 6.7) and OR (CI) = 2.1 (1.2, 3.7), respectively). Monoethyl phthalate (MEP) was associated with later implantation (10–12 days vs. 9 days); OR (CI) = 1.5 (1.0, 2.1). Compared with implantation on day 9, BPA was significantly associated with both earlier and later implantation (OR=2.2 for both). Women with concentrations above the median of monobenzyl phthalate (MBzP) (p=0.04) or above the median of the molar sum of four di(2-ethylhexyl) phthalate metabolites (∑DEHP) (p=0.08) had a slower initial rise in hCG. Increasing MCPP was associated with an increased odds of a late rise rescue (OR (CI) = 2.9 (1.0, 8.5); late rise vs. early rise), while increasing MEP was associated with a no rise rescue (OR (CI) = 1.6 (0.9, 2.8); no rise vs. early rise). The reported associations varied in their direction of effect, some potentially protective, others adverse. This may reflect the complexity with which these potential endocrine disrupting chemicals can be acting, but chance findings are also possible. Given that women continue to be exposed to these compounds (or their precursors), continued research on the effects they may have on pregnancy is warranted.
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影响因子：
82.9
作者：
Cha J;Sun X;Dey SK
通讯作者：
Dey SK
影响因子：
11.8
作者：
Ferguson, Kelly K.;McElrath, Thomas F.;Ko, Yi-An;Mukherjee, Bhramar;Meeker, John D.
通讯作者：
Meeker, John D.
邻苯二甲酸酯代谢产物的尿液浓度和受过医学辅助繁殖的妇女的妊娠损失。
DOI：
10.1097/ede.0000000000000525
发表时间：
2016-11
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Messerlian C;Wylie BJ;Mínguez-Alarcón L;Williams PL;Ford JB;Souter IC;Calafat AM;Hauser R;Earth Study Team
通讯作者：
Earth Study Team
影响因子：
10.4
作者：
Jukic AM;Calafat AM;McConnaughey DR;Longnecker MP;Hoppin JA;Weinberg CR;Wilcox AJ;Baird DD
通讯作者：
Baird DD
影响因子：
158.5
作者：
Hoover, Robert N.;Hyer, Marianne;Troisi, Rebecca
通讯作者：
Troisi, Rebecca