Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth.
Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth.
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DOI：
10.1016/j.envint.2014.05.016
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发表时间：
2014-09
影响因子：
11.8
通讯作者：
Meeker, John D.
中科院分区：
文献类型：
--
作者：
Ferguson, Kelly K.;McElrath, Thomas F.;Ko, Yi-An;Mukherjee, Bhramar;Meeker, John D.
早产是一个重大的公共卫生问题，影响超过十分之一的活产，并在很大程度上导致婴儿死亡率和发病率。每天接触邻苯二甲酸盐等环境化学物质可能会造成这种情况，并且可能是可以改变的。在本研究中，我们检查了妊娠期间邻苯二甲酸盐暴露的变异性，并确定了与早产关系的易感性窗口。作为马萨诸塞州波士顿布莱根妇女医院前瞻性纵向出生队列的一部分，女性在怀孕早期被招募。在妊娠期间最多 4 个时间点收集尿液样本进行邻苯二甲酸盐测量，并在分娩时记录出生结果。我们从这个人群中选择了所有 130 例早产病例（定义为在妊娠 37 周之前分娩）以及 352 例随机对照。尿邻苯二甲酸酯代谢物水平在怀孕期间有适度的变化，但在多个时间点测量的水平与早产几率增加相关。自发性早产的调整优势比 (aOR) 与妊娠晚期开始时测量的邻苯二甲酸酯代谢物浓度的相关性最强（邻苯二甲酸二-2-乙基己酯代谢物的 aOR 总和 [ΣDEHP]=1.33，95% 置信区间 [CI]=1.02、1.73）。胎盘早产（定义为出现先兆子痫或宫内生长受限的分娩）的优势比在妊娠早期对于 DEHP 代谢物略有升高（ΣDEHP 的 aOR=1.33，95% CI=0.99，1.78）。在怀孕早期和晚期接触邻苯二甲酸盐的孕妇早产的风险会增加，但机制可能因病因而异。
Preterm birth is a significant public health problem, affecting over 1 in 10 live births and contributing largely to infant mortality and morbidity. Everyday exposure to environmental chemicals such as phthalates could contribute, and may be modifiable. In the present study we examine variability in phthalate exposure across gestation and identify windows of susceptibility for the relationship with preterm birth. Women were recruited early in pregnancy as part of a prospective, longitudinal birth cohort at the Brigham and Women’s Hospital in Boston, Massachusetts. Urine samples were collected at up to 4 time points during gestation for phthalate measurement, and birth outcomes were recorded at delivery. From this population we selected all 130 cases of preterm birth, defined as delivery before 37 weeks completed gestation, as well as 352 random controls. Urinary phthalate metabolite levels were moderately variable over pregnancy, but levels measured at multiple time points were associated with increased odds of preterm birth. Adjusted odds ratios (aOR) for spontaneous preterm birth were strongest in association with phthalate metabolite concentrations measured at the beginning of the third trimester (aOR for summed di-2-ethylhexyl phthalate metabolites [∑DEHP]=1.33, 95% confidence interval [CI]=1.02, 1.73). Odds ratios for placental preterm birth, defined as delivery with presentation of preeclampsia or intrauterine growth restriction, were slightly elevated in the first trimester for DEHP metabolites (aOR for ∑DEHP=1.33, 95% CI=0.99, 1.78). Pregnant women with exposure to phthalates both early and late in pregnancy are at increased risk of delivering preterm, but mechanisms may differ based on etiology.
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影响因子：
11.4
作者：
Frederiksen, Hanne;Kranich, Selma K.;Andersson, Anna-Maria
通讯作者：
Andersson, Anna-Maria
暴露于环境内分泌破坏者和儿童发育。
DOI：
10.1001/archpediatrics.2012.241
发表时间：
2012-06-01
影响因子：
--
作者：
Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
3.5
作者：
Hong, Yun-Chul;Park, Eun-Young;Ha, Eun-Hee
通讯作者：
Ha, Eun-Hee
影响因子：
4.8
作者：
Fan, Jinjiang;Traore, Kassim;Papadopoulos, Vassilios
通讯作者：
Papadopoulos, Vassilios
影响因子：
--
作者：
Bornehag, C. G.;Nanberg, E.
通讯作者：
Nanberg, E.