Pupil fluctuations track fast switching of cortical states during quiet wakefulness.
Pupil fluctuations track fast switching of cortical states during quiet wakefulness.
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DOI：
10.1016/j.neuron.2014.09.033
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发表时间：
2014-10-22
期刊：
影响因子：
16.2
通讯作者：
Tolias, Andreas S.
中科院分区：
文献类型：
--
作者：
Reimer, Jacob;Froudarakis, Emmanouil;Cadwell, Cathryn R.;Yatsenko, Dimitri;Denfield, George H.;Tolias, Andreas S.
神经反应受大脑状态的调节，大脑状态随觉醒、注意力和行为而变化。在老鼠身上，奔跑和拍打会使大脑皮层失去同步，增强感觉反应，但探索行为之间的静止期尚未得到充分研究。我们发现这些“安静清醒”时期的特征是在1-2秒的时间尺度上的状态波动。瞳孔直径的微小波动追踪了多个皮质区域的状态转变。在扩张期间，细胞膜内电位不同步，感觉反应增强，种群活动相关性较低。相比之下，收缩的特征是低频振荡增加和更高的系综相关性。特定的皮层中间神经元亚型在扩张和收缩期间被不同地激活，这与它们参与观察到的状态变化一致。瞳孔测定法已被用来衡量人类的注意力和脑力活动，但这种现象背后的细胞内动力学和群体活动差异以前是未知的。
Neural responses are modulated by brain state, which varies with arousal, attention, and behavior. In mice, running and whisking desynchronize the cortex and enhance sensory responses, but the quiescent periods between bouts of exploratory behaviors have not been well-studied. We found that these periods of “quiet wakefulness” were characterized by state fluctuations on a timescale of 1–2 seconds. Small fluctuations in pupil diameter tracked these state transitions in multiple cortical areas. During dilation, the intracellular membrane potential was desynchronized, sensory responses were enhanced, and population activity was less correlated. In contrast, constriction was characterized by increased low-frequency oscillations and higher ensemble correlations. Specific subtypes of cortical interneurons were differentially activated during dilation and constriction, consistent with their participation in the observed state changes. Pupillometry has been used to index attention and mental effort in humans, but the intracellular dynamics and differences in population activity underlying this phenomenon were previously unknown.
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影响因子：
16.2
作者：
Bennett C;Arroyo S;Hestrin S
通讯作者：
Hestrin S
影响因子：
2.5
作者：
Hei, Xiaojuan;Stoelzel, Carl R.;Swadlow, Harvey A.
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Swadlow, Harvey A.
影响因子：
10.6
作者：
Aston-Jones, G;Rajkowski, J;Cohen, J
通讯作者：
Cohen, J
DOI：
10.3758/cabn.10.2.252
发表时间：
2010-05
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Gilzenrat MS;Nieuwenhuis S;Jepma M;Cohen JD
通讯作者：
Cohen JD
影响因子：
16.2
作者：
Niell CM;Stryker MP
通讯作者：
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