Association between SOD2 V16A variant and urological cancer risk
Association between SOD2 V16A variant and urological cancer risk
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SOD2 V16A 变异与泌尿系统癌症风险之间的关联
DOI：
10.18632/aging.102658
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Li-Jie Zhu
中科院分区：
文献类型：
--
作者：
Li-Feng Zhang;Kai Xu;Bo-Wen Tang;Wei Zhang;Wei Yuan;Chuang Yue;Li Shi;Yuan-Yuan Mi;Li Zuo;Li-Jie Zhu
背景资料：超氧化物歧化酶2（SOD 2）V16 A变异体与泌尿系肿瘤易感性之间的相关性已被广泛研究，但结果存在分歧。结果：共纳入9，910例癌症患者和11，239例对照受试者。V16 A变异与泌尿系统癌症易感性增加相关（A等位基因vs. V等位基因：OR = 1.06，95% CI = 1.00 - 1.13，P = 0.047; AA+AV vs. VV：OR = 1.09，95% CI = 1.02 - 1.16，P = 0.008），尤其是前列腺癌（PCa）。VV+VA基因型PCa患者血清SOD 2水平低于AA基因型。与对照相比，SOD 2表达在前列腺癌和膀胱癌中均下调。此外，与早期阶段的参与者相比，在更先进的PCa参与者中发现SOD 2下调。SOD 2低表达的PCa受试者与SOD 2高表达的受试者相比，无病生存期（DFS）较短。结论：SOD 2 V16 A变异可能与泌尿系肿瘤易感性增加相关，尤其是前列腺癌。方法：采用比值比（OR）、计算机模拟工具和ELISA进行汇总分析，以证明这种关联。我们还使用免疫组织化学染色（IHS）来评估SOD 2表达。
Background: The correlation between superoxide dismutase 2 (SOD2) V16A variant and urological cancer susceptibility has been widely studied, however, with divergent results. Results: Totally, 9,910 cancer patients and 11,239 control subjects were enrolled. V16A variant is associated with an increased susceptibility to urological cancer (A-allele vs. V-allele: OR = 1.06, 95% CI = 1.00 – 1.13, P = 0.047; AA+AV vs. VV: OR = 1.09, 95% CI = 1.02 – 1.16, P = 0.008), especially for prostate cancer (PCa). Serum SOD2 level of PCa patients with VV+VA genotypes was lower than in those with AA genotypes. SOD2 expression is downregulated in both prostate and bladder cancer, as compared to the control. Furthermore, SOD2 was found to be downregulated in more advanced PCa participants, as compared to the ones in early stages. PCa subjects with low SOD2 expression displayed a shorter disease-free survival (DFS) time compared to that of the high SOD2 expression counterparts. Conclusions: The SOD2 V16A variant may be associated with increased urological cancer susceptibility, especially for prostate cancer. Methods: A pooled analysis utilizing odds ratios (ORs), in silico tools and ELISA was adopted to demonstrate this association. We also used immunohistochemical staining (IHS) to assess SOD2 expression.
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影响因子：
1.4
作者：
Atilgan D;Parlaktas BS;Uluocak N;Kolukcu E;Erdemir F;Ozyurt H;Erkorkmaz U
通讯作者：
Erkorkmaz U
影响因子：
4.2
作者：
J. Stoehlmacher;S. Ingles;D. Park;Wu Zhang;H. Lenz
通讯作者：
J. Stoehlmacher;S. Ingles;D. Park;Wu Zhang;H. Lenz
影响因子：
--
作者：
Wang P;Zhu Y;Xi S;Li S;Zhang Y
通讯作者：
Zhang Y
影响因子：
6.6
作者：
Ichimura, Y;Habuchi, T;Kato, T
通讯作者：
Kato, T
DOI：
10.1007/s12032-015-0700-1
发表时间：
2015-11-01
期刊：
Medical oncology (Northwood, London, England)
影响因子：
--
作者：
Berto, Maiquidieli Dal;Bica, Claudia Giuliano;da Cruz, Ivana Beatrice Manica
通讯作者：
da Cruz, Ivana Beatrice Manica