Prognostic value of carbonic anhydrase IX immunohistochemical expression in renal cell carcinoma: a meta-analysis of the literature.
Prognostic value of carbonic anhydrase IX immunohistochemical expression in renal cell carcinoma: a meta-analysis of the literature.
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肾细胞癌中碳酸酐酶 IX 免疫组织化学表达的预后价值：文献荟萃分析
DOI：
10.1371/journal.pone.0114096
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fernando S
中科院分区：
文献类型：
--
作者：
Zhao Z;Liao G;Li Y;Zhou S;Zou H;Fernando S
Background Carbonic anhydrase IX (CAIX) protein has been correlated with progression and survival in patients with renal cell carcinoma (RCC). The prognostic value of CAIX in RCC however, remains inconclusive according to published works. This study aimed to analyze CAIX as a biological marker to predict RCC patient prognosis. Methods A literature search of the PubMed and Web of Knowledge databases was performed to retrieve original studies from their inception to December of 2013. Fifteen studies, collectively including a total of 2611 patients with renal cell carcinoma, were carefully reviewed. Standard meta-analysis methods were applied to evaluate the prognostic impact of CAIX expression on patient prognosis. The hazard ratio (HR) and its 95% confidence interval (CI) were recorded for the relationship between CAIX expression and survival, and the data were analyzed using Review Manager 5.2 software and Stata software 11.0. Results In patients with RCC, low CAIX expression was associated with poor disease-specific survival (HR = 1.89, 95% CI: 1.20–2.98, P = 0.006), unfavorable progression-free survival (HR = 2.62, 95% CI: 1.14–6.05, P = 0.02) and worse overall survival (HR = 2.03, 95% CI: 1.28–3.21, P = 0.002). Furthermore, low CAIX expression was significantly associated with the presence of lymph node metastases (odds ratio (OR) = 0.31, 95% CI = 0.15–0.62, P = 0.0009) and distant metastases (OR = 0.66, 95% CI = 0.46–0.96, P = 0.03) and predicted a higher tumor grade (OR = 0.41, 95% CI = 0.31–0.54, P<0.00001). Conclusions Low CAIX expression most likely indicates poor prognosis in RCC patients. Moreover, low CAIX expression was significantly associated with unfavorable clinicopathological factors. To strengthen our findings, further well-designed prospective studies should be conducted to investigate the role of CAIX expression in RCC.
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影响因子：
3.7
作者：
Dornbusch J;Zacharis A;Meinhardt M;Erdmann K;Wolff I;Froehner M;Wirth MP;Zastrow S;Fuessel S
通讯作者：
Fuessel S
影响因子：
9
作者：
Driessen, A;Landuyt, W;Ectors, N
通讯作者：
Ectors, N
影响因子：
11.5
作者：
Atkins, M;Regan, M;Signoretti, S
通讯作者：
Signoretti, S
影响因子：
7.5
作者：
Brunelli, Matteo;Eccher, Albino;Martignoni, Guido
通讯作者：
Martignoni, Guido
影响因子：
45.3
作者：
Jensen, Hanne Krogh;Donskov, Frede;von der Maase, Hans
通讯作者：
von der Maase, Hans