Local treatment of non healing leg ulcers in a patient with hepatitis C virus infection.

Local treatment of non healing leg ulcers in a patient with hepatitis C virus infection.
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丙型肝炎病毒感染患者不愈合的腿部溃疡的局部治疗。

DOI:
10.1111/iwj.12106
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发表时间:
2015
影响因子:
3.1
通讯作者:
Fino,Pasquale
Fino,Pasquale
中科院分区:
医学3区
文献类型:
--
作者:
Onesti,MariaG;Fioramonti,Paolo;Massera,Diego;Amorosi,Vittoria;Fino,Pasquale

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丙型肝炎病毒(HCV)是一种血液传播的病毒,通过明显和不明显的胃肠外途径传播,通常与自身免疫性肝外并发症有关(1)。皮肤是最常受影响的器官之一,经常与HCV感染相关的主要皮肤病包括混合性冷球蛋白血症、皮肤性卟啉病、可触及紫癜、皮肤扁平苔藓和坏死性血管炎,通常伴有非常疼痛的腿部溃疡。其他可能与丙型肝炎相关的皮肤疾病包括白塞综合征、多形性红斑和结节性红斑、软化斑、荨麻疹和瘙痒症(2)。由皮肤血管炎引起的腿部溃疡可能与cryopulins有关,也可能无关(3)。这是一种难以治疗的慢性、不愈合的溃疡,对心理社会方面和身体健康都有重大影响(4,5)。我们报告一例57岁的女性前吸毒者,患有HCV感染10年,心脏病,高血压和动静脉病变。她出现了持续3年的左右大腿不愈合溃疡(图1)。在入院前的3年中,患者每月接受一次全科医生的治疗,每周接受两次家庭护理团队的治疗。患者于2011年首次在我们的门诊就诊,
Dear Editors, Infection with hepatitis C virus (HCV), a blood-borne agent, is transmitted by apparent and inapparent parenteral procedures, frequently associated with autoimmune extrahepatic complications (1). Skin is one of the most frequently affected organs and the major skin diseases frequently associated with HCV infection include mixed cryoglobulinemia, porphyria cutaneatarda, palpable purpura, lichen planus cutaneous and necrotising vasculitis, often with very painful leg ulcers. Other skin disorders that may also be linked to hepatitis C are Behçet syndrome, erythaema multiforme and nodosum, malacoplakia, urticaria and pruritus (2). The leg ulcers due to cutaneous vasculitis may or may not be associated to cryoglobulins (3). These are chronic, nonhealing ulcers difficult to treat with a significant impact on psychosocial aspects as well as on one’s physical well-being (4, 5).We present a case of a 57-year-old female ex-addict who has been suffering from HCV infection for 10years, cardiopathy, hypertension and arterio-venous pathology. She presented with non-healing ulcers over her right and left thighs for a duration of 3 years (Figure 1). During the 3 years prior to the admission, the patient was treated monthly by her general practitioner and twice a week by a home-care team. The patient was visited at first, in 2011, in our Ambulatory
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