Increasing empathic concern relates to salience network hyperconnectivity in cognitively healthy older adults with elevated amyloid-β burden.
Increasing empathic concern relates to salience network hyperconnectivity in cognitively healthy older adults with elevated amyloid-β burden.
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DOI：
10.1016/j.nicl.2022.103282
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发表时间：
2023
影响因子：
4.2
通讯作者：
Sturm, Virginia E.
中科院分区：
文献类型：
--
作者：
Chow, Tiffany E.;Veziris, Christina R.;La Joie, Renaud;Lee, Alex J.;Brown, Jesse A.;Yokoyama, Jennifer S.;Rankin, Katherine P.;Kramer, Joel H.;Miller, Bruce L.;Rabinovici, Gil D.;Seeley, William W.;Sturm, Virginia E.
关键词：
共情关怀是一种以他人为导向的情感共情，可以促进同情心。β淀粉样蛋白阳性的健康老年人具有更大的共情关注增益。β淀粉样蛋白阳性与更大的显著性网络连接有关。移情关注预测了淀粉样蛋白-β阳性组的显著性网络超连通性。增强的情感同理心，分享他人情感体验的能力，可能是阿尔茨海默病（AD）的一个特征，但情感同理心是否在疾病的临床前阶段增加尚不清楚。我们测量了86名老年人在认知健康、功能正常和无痴呆症状的时期内随时间推移的情感同理心（范围= 0 - 7.3年，平均= 2.4年）。对于每个参与者，我们计算了移情关注的纵向轨迹（即，一种促进亲社会行为的情绪同理心的面向他人的形式）和情绪传染（即，一种以自我为中心的情感共情形式，通常伴随着痛苦的感觉）。使用淀粉样β（Aβ）正电子发射断层扫描（PET）扫描，根据Aβ-PET皮质结合将受试者分为Aβ阳性（Aβ+，n = 23）或阴性（Aβ-，n = 63）。参与者还在最后一次同理心评估后平均两年接受了结构和无任务功能磁共振成像，当时大多数参与者保持认知健康。结果表明，尽管在第一次测量时没有初始组差异，但随着时间的推移，Aβ+参与者的共情关注（而不是情绪感染）比Aβ-参与者增加得更多。某些显著性网络节点对之间的更高连接性（即，膝前扣带皮层和导水管周围灰质）预测了Aβ+组共情关注的纵向增加，但在Aβ-组中没有。Aβ+参与者的整体显着网络连接性也高于Aβ-参与者，尽管灰质体积没有差异。这些结果表明，共情关注的收益可能是AD病理生理学的一个非常早期的特征，与显着网络中的超连接有关，显着网络是一个支持情绪生成和内感受的系统。更好地理解AD病理生理学早期阶段的情感移情轨迹将拓宽临床前AD变化的透镜，并帮助临床医生识别应筛查AD生物标志物的老年人。
Empathic concern is an other-oriented emotional empathy that fosters compassion. Amyloid-β positive healthy older adults had greater empathic concern gains. Amyloid-β positivity related to greater salience network connectivity. Empathic concern predicted salience network hyperconnectivity in the amyloid-β positive group. Enhanced emotional empathy, the ability to share others’ affective experiences, can be a feature of Alzheimer’s disease (AD), but whether emotional empathy increases in the preclinical phase of the disease is unknown. We measured emotional empathy over time (range = 0 – 7.3 years, mean = 2.4 years) in 86 older adults during a period in which they were cognitively healthy, functionally normal, and free of dementia symptoms. For each participant, we computed longitudinal trajectories for empathic concern (i.e., an other-oriented form of emotional empathy that promotes prosocial actions) and emotional contagion (i.e., a self-focused form of emotional empathy often accompanied by feelings of distress) from informant ratings of participants’ empathy on the Interpersonal Reactivity Index. Amyloid-β (Aβ) positron emission tomography (PET) scans were used to classify participants as either Aβ positive (Aβ+, n = 23) or negative (Aβ-, n = 63) based on Aβ-PET cortical binding. Participants also underwent structural and task-free functional magnetic resonance imaging approximately two years on average after their last empathy assessment, at which time most participants remained cognitively healthy. Results indicated that empathic concern, but not emotional contagion, increased more over time in Aβ+ participants than in Aβ- participants despite no initial group difference at the first measurement. Higher connectivity between certain salience network node-pairs (i.e., pregenual anterior cingulate cortex and periaqueductal gray) predicted longitudinal increases in empathic concern in the Aβ+ group but not in the Aβ- group. The Aβ+ participants also had higher overall salience network connectivity than Aβ- participants despite no differences in gray matter volume. These results suggest gains in empathic concern may be a very early feature of AD pathophysiology that relates to hyperconnectivity in the salience network, a system that supports emotion generation and interoception. A better understanding of emotional empathy trajectories in the early stages of AD pathophysiology will broaden the lens on preclinical AD changes and help clinicians to identify older adults who should be screened for AD biomarkers.
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影响因子：
3.7
作者：
CARSTENSEN, LL
通讯作者：
CARSTENSEN, LL
影响因子：
5.7
作者：
Barnes, Josephine;Ridgway, Gerard R.;Fox, Nick C.
通讯作者：
Fox, Nick C.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
4.8
作者：
Balthazar, Marcio L. F.;Pereira, Fabricio R. S.;Cendes, Fernando
通讯作者：
Cendes, Fernando
DOI：
10.1111/j.1468-2389.2007.00371.x
发表时间：
2007-03-01
影响因子：
2.2
作者：
Connolly, James J.;Kavanagh, Erin J.;Viswesvaran, Chockalingam
通讯作者：
Viswesvaran, Chockalingam