The Potential Role of an Aberrant Mucosal Immune Response to SARS-CoV-2 in the Pathogenesis of IgA Nephropathy.
The Potential Role of an Aberrant Mucosal Immune Response to SARS-CoV-2 in the Pathogenesis of IgA Nephropathy.
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对 SARS-CoV-2 的异常粘膜免疫反应在 IgA 肾病发病机制中的潜在作用
DOI：
10.3390/pathogens10070881
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发表时间：
2021-07-12
期刊：
影响因子：
--
通讯作者：
Zhu S
中科院分区：
文献类型：
--
作者：
Zhang Z;Zhang G;Guo M;Tao W;Liu X;Wei H;Jin T;Zhang Y;Zhu S
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的爆发已成为全球关注的问题。免疫球蛋白A（伊加）有助于在感染的早期阶段中和病毒。需要进行纵向研究，以评估SARS-CoV-2特异性伊加的产生是否在从严重COVID-19中恢复的患者中持续更长时间，并且还应提醒易感宿主注意可能导致致残后果的持续症状。在这里，我们追踪了88名COVID-19患者队列中的抗SARS-CoV-2刺突蛋白受体结合域（RBD）抗体水平。我们发现52.3%的患者产生的抗SARS-CoV-2 RBD伊加高于IgG或IgM，并且伊加水平在感染的4-41天内保持稳定。其中一名IgA占主导地位的COVID-19患者同时患有伊加肾病（IgAN），在感染期间出现血清肌酐升高和蛋白尿恶化，一直持续到感染后7个月。患者血清抗SARS-CoV-2 RBD和总伊加水平均高于健康对照组。肠道微生物群组成的变化、伊加高度包被的细菌增加以及促炎细胞因子IL-18浓度升高表明肠道生态失调和炎症可能涉及全身伊加水平，因此可能涉及疾病进展。总的来说，我们的工作强调了对SARS-CoV-2感染的粘膜免疫反应的潜在不利影响，并且应该对患有IgAN等慢性疾病的COVID-19患者采取额外的护理。
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global concern. Immunoglobin A (IgA) contributes to virus neutralization at the early stage of infection. Longitudinal studies are needed to assess whether SARS-CoV-2-specific IgA production persists for a longer time in patients recovered from severe COVID-19 and its lasting symptoms that can have disabling consequences should also be alerted to susceptible hosts. Here, we tracked the anti-SARS-CoV-2 spike protein receptor-binding domain (RBD) antibody levels in a cohort of 88 COVID-19 patients. We found that 52.3% of the patients produced more anti-SARS-CoV-2 RBD IgA than IgG or IgM, and the levels of IgA remained stable during 4–41 days of infection. One of these IgA-dominant COVID-19 patients, concurrently with IgA nephropathy (IgAN), presented with elevated serum creatinine and worse proteinuria during the infection, which continued until seven months post-infection. The serum levels of anti-SARS-CoV-2 RBD and total IgA were higher in this patient than in healthy controls. Changes in the composition of the intestinal microbiota, increased IgA highly coated bacteria, and elevated concentration of the proinflammatory cytokine IL-18 were indicative of potential involvement of intestinal dysbiosis and inflammation to the systemic IgA level and, consequently, the disease progression. Collectively, our work highlighted the potential adverse effect of the mucosal immune response to SARS-CoV-2 infection, and that additional care should be taken with COVID-19 patients presenting with chronic diseases such as IgAN.
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影响因子：
12.2
作者：
Pascoal LB;Rodrigues PB;Genaro LM;Gomes ABDSP;Toledo-Teixeira DA;Parise PL;Bispo-Dos-Santos K;Simeoni CL;Guimarães PV;Buscaratti LI;Elston JGA;Marques-Souza H;Martins-de-Souza D;Ayrizono MLS;Velloso LA;Proenca-Modena JL;Moraes-Vieira PMM;Mori MAS;Farias AS;Vinolo MAR;Leal RF
通讯作者：
Leal RF
IGA主导对SARS-COV-2的早期中和抗体反应。
影响因子：
17.1
作者：
Sterlin D;Mathian A;Miyara M;Mohr A;Anna F;Claër L;Quentric P;Fadlallah J;Devilliers H;Ghillani P;Gunn C;Hockett R;Mudumba S;Guihot A;Luyt CE;Mayaux J;Beurton A;Fourati S;Bruel T;Schwartz O;Lacorte JM;Yssel H;Parizot C;Dorgham K;Charneau P;Amoura Z;Gorochov G
通讯作者：
Gorochov G
影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
32.4
作者：
Quast I;Tarlinton D
通讯作者：
Tarlinton D
影响因子：
29.7
作者：
Cerutti A;Chen K;Chorny A
通讯作者：
Chorny A