Sex difference in bronchopulmonary dysplasia of offspring in response to maternal PM2.5 exposure.
Sex difference in bronchopulmonary dysplasia of offspring in response to maternal PM2.5 exposure.
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后代支气管肺发育不良对母亲 PM2.5 暴露的反应的性别差异。
DOI：
10.1016/j.jhazmat.2020.122033
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发表时间：
2020-01
影响因子：
13.6
通讯作者：
Nan Sang
中科院分区：
文献类型：
--
作者：
Huifeng Yue;Xiaotong Ji;Tingting Ku;Guangke Li;Nan Sang
细颗粒物（PM2.5）对呼吸道疾病的不利影响始于子宫。为了探讨PM2.5暴露是否会导致子代支气管肺发育不良（BPD），在山西太原市每年采暖期采集PM2.5样本。小鼠交配，妊娠第0天（GD 0）视为观察到阴道栓的日期。plug阳性小鼠接受3 mg/kg b.w.从GD 0开始和整个妊娠期，每隔一天通过口咽抽吸测量PM2.5。在出生后第1、7、14和21天处死后代。我们评估了一些典型的BPD样症状的后代。结果表明，母亲PM2.5暴露导致低出生体重，肺泡发育不良，血管生成减少，分泌和表面活性蛋白的产生受到抑制，并增加了男性后代肺部的炎症。然而，母体PM2.5暴露仅诱导雌性后代肺部肺泡发育不良和炎症。此外，这些变化在出生后发育过程中被逆转。研究结果表明，母亲暴露于PM2.5可引起子代可逆的BPD相关后果，且雄性子代比雌性子代更敏感。然而，这些变化在出生后的发展过程中被逆转。
The adverse effects of fine particulate matters (PM2.5) on respiratory diseases startin utero. In order to investigate whether maternal PM2.5exposure could lead to bronchopulmonary dysplasia (BPD) in offspring, PM2.5was collected in Taiyuan, Shanxi, China during the annual heating period. Mice were mated and gestation day 0 (GD0) was considered the day on which a vaginal plug was observed. The plug-positive mice received 3 mg/kg b.w. PM2.5by oropharyngeal aspiration every other day starting on GD0 and throughout the gestation period. Offspring were sacrificed at postnatal days (PNDs) 1, 7, 14 and 21. We assessed some typical BPD-like symptoms in offspring. The results showed that maternal PM2.5exposure caused low birth weight, hypoalveolarization, decreased angiogenesis, suppressed production of secretory and surfactant proteins, and increased inflammation in the lungs of male offspring. However, maternal PM2.5exposure induced only hypoalveolarization and inflammation in the lungs of female offspring. Furthermore, these alterations were reversed during postnatal development. Our results demonstrated that maternal exposure to PM2.5caused reversible BPD-related consequences in offspring, and male offspring were more sensitive than females. However, these alterations were reversed during postnatal development.
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影响因子：
2.5
作者：
Boström, H;Gritli-Linde, A;Betsholtz, C
通讯作者：
Betsholtz, C
影响因子：
10.4
作者：
Sarah Todd Davidson
通讯作者：
Sarah Todd Davidson
DOI：
10.1186/s40348-016-0051-9
发表时间：
2016-12
期刊：
Molecular and cellular pediatrics
影响因子：
--
作者：
Shahzad T;Radajewski S;Chao CM;Bellusci S;Ehrhardt H
通讯作者：
Ehrhardt H
影响因子：
10
作者：
Chang YC;Cole TB;Costa LG
通讯作者：
Costa LG
DOI：
10.4049/jimmunol.1700014
发表时间：
2017-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Singh SP;Chand HS;Langley RJ;Mishra N;Barrett T;Rudolph K;Tellez C;Filipczak PT;Belinsky S;Saeed AI;Sheybani A;Exil V;Agarwal H;Sidhaye VK;Sussan T;Biswal S;Sopori M
通讯作者：
Sopori M