The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.
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DOI:
10.1016/j.ccell.2018.03.015
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发表时间:
2018-04-09
期刊:
影响因子:
50.3
通讯作者:
Wargo JA
Wargo JA
中科院分区:
医学1区
文献类型:
--
作者:
Gopalakrishnan V;Helmink BA;Spencer CN;Reuben A;Wargo JA

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The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may impact responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome’s influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.
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