Psychophysiological Interactions in a Visual Checkerboard Task: Reproducibility, Reliability, and the Effects of Deconvolution.
Psychophysiological Interactions in a Visual Checkerboard Task: Reproducibility, Reliability, and the Effects of Deconvolution.
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DOI：
10.3389/fnins.2017.00573
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发表时间：
2017
影响因子：
4.3
通讯作者：
Biswal BB
中科院分区：
文献类型：
--
作者：
Di X;Biswal BB
心理生理交互作用（PPI）是一种基于回归的方法，用于研究任务调节的大脑连接性。尽管它在功能性磁共振成像（fMRI）研究中很受欢迎，但其可靠性和可重复性尚未得到评估。我们研究了在一个简单视觉任务中PPI效应的可重复性和可靠性，并检验了去卷积对PPI结果的影响。对一个大型的开放获取数据集（n = 138）进行了分析，其中一个视觉任务分别以645毫秒和1400毫秒的重复时间（TR）进行了两次扫描。我们首先以左侧和右侧枕中回为种子重复了我们之前的结果。然后在20个视觉相关的丘脑和皮质区域中进行了感兴趣区域（ROI）分析，并且发现许多区域之间存在负的PPI效应，其中梭状回后部为一个枢纽区域。基于种子和基于ROI的结果在两次运行之间以及在有和没有去卷积的两种PPI方法之间是相似的。一般来说，非去卷积方法和短TR运行具有更大的效应量和更广泛的范围。然而，在体素分析中，去卷积方法在645毫秒TR运行中的表现比1400毫秒TR运行更差。鉴于两种方法之间结果大致相似以及去卷积的不确定性，我们建议对于组块设计数据的PPI分析，去卷积可能不是必需的。最后，两次运行之间的组内相关系数（ICC）对于PPI效应来说比激活主效应要低得多，这对进行PPI效应的个体间相关和组间比较提出了警示。
Psychophysiological interaction (PPI) is a regression based method to study task modulated brain connectivity. Despite its popularity in functional MRI (fMRI) studies, its reliability and reproducibility have not been evaluated. We investigated reproducibility and reliability of PPI effects during a simple visual task, and examined the effect of deconvolution on the PPI results. A large open-access dataset was analyzed (n = 138), where a visual task was scanned twice with repetition times (TRs) of 645 and 1,400 ms, respectively. We first replicated our previous results by using the left and right middle occipital gyrus as seeds. Then regions of interest (ROI)-wise analysis was performed among 20 visual-related thalamic and cortical regions, and negative PPI effects were found between many ROIs with the posterior fusiform gyrus as a hub region. Both the seed-based and ROI-wise results were similar between the two runs and between the two PPI methods with and without deconvolution. The non-deconvolution method and the short TR run in general had larger effect sizes and greater extents. However, the deconvolution method performed worse in the 645 ms TR run than the 1,400 ms TR run in the voxel-wise analysis. Given the general similar results between the two methods and the uncertainty of deconvolution, we suggest that deconvolution may be not necessary for PPI analysis on block-designed data. Lastly, intraclass correlations (ICC) between the two runs were much lower for the PPI effects than the activation main effects, which raise cautions on performing inter-subject correlations and group comparisons on PPI effects.
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影响因子：
3.1
作者：
Caspers, Julian;Zilles, Karl;Eickhoff, Simon B.;Schleicher, Axel;Mohlberg, Hartmut;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
3.1
作者：
Kujovic, Milenko;Zilles, Karl;Malikovic, Aleksandar;Schleicher, Axel;Mohlberg, Hartmut;Rottschy, Claudia;Eickhoff, Simon B.;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
2.5
作者：
Di, Xin;Biswal, Bharat B.
通讯作者：
Biswal, Bharat B.
DOI：
10.1073/pnas.1608117113
发表时间：
2016-10-25
影响因子：
11.1
作者：
Lewis, Laura D.;Setsompop, Kawin;Polimeni, Jonathan R.
通讯作者：
Polimeni, Jonathan R.
影响因子：
5.7
作者：
Makni, Salima;Beckmann, Christian;Woolrich, Mark
通讯作者：
Woolrich, Mark