Cytoarchitectonic mapping of the human dorsal extrastriate cortex.

Cytoarchitectonic mapping of the human dorsal extrastriate cortex.
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DOI:
10.1007/s00429-012-0390-9
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发表时间:
2013-01
影响因子:
3.1
通讯作者:
Amunts, Katrin
Amunts, Katrin
中科院分区:
医学3区
文献类型:
--
作者:
Kujovic, Milenko;Zilles, Karl;Malikovic, Aleksandar;Schleicher, Axel;Mohlberg, Hartmut;Rottschy, Claudia;Eickhoff, Simon B.;Amunts, Katrin

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背侧视觉流由几个功能专门化的区域组成,但它们的大多数细胞结构相关性尚未在人脑中被确定。因此,在连续切片的10个人死后的大脑,使用形态测量和多变量统计分析的定义区域边界的布罗德曼区18/V2附近的皮质进行了分析。检测到两个以前未知的细胞结构区域(hOc 3d,hOc 4d)。它们占据枕叶的内侧表面,在较小程度上,也占据枕叶的外侧表面。较大的区域hOc 3d位于上级和横枕区域以及顶枕沟中V2区的背外侧。区域hOC 4d被鉴定为hOC 3d的吻侧;它与后者的不同之处在于较低层III中的较大锥体细胞,较薄的层V和VI,以及尖锐的皮质-白质边界。在解剖MNI空间中叠加所描绘的区域,并计算概率图。它们在体积和位置上显示出相对较高的受试者间变异性。基于它们的位置和邻近关系,区域hOc 3d和hOc 4d是功能定义区域V3 d和V3 a的假定解剖学基底,现在可以通过比较概率细胞结构图和活人脑的激活研究来验证这一假设。
The dorsal visual stream consists of several functionally specialized areas, but most of their cytoarchitectonic correlates have not yet been identified in the human brain. The cortex adjacent to Brodmann area 18/V2 was therefore analyzed in serial sections of ten human post-mortem brains using morphometrical and multivariate statistical analyses for the definition of areal borders. Two previously unknown cytoarchitectonic areas (hOc3d, hOc4d) were detected. They occupy the medial and, to a smaller extent, lateral surface of the occipital lobe. The larger area, hOc3d, is located dorso-lateral to area V2 in the region of superior and transverse occipital, as well as parieto-occipital sulci. Area hOc4d was identified rostral to hOc3d; it differed from the latter by larger pyramidal cells in lower layer III, thinner layers V and VI, and a sharp cortex-white-matter borderline. The delineated areas were superimposed in the anatomical MNI space, and probabilistic maps were calculated. They show a relatively high intersubject variability in volume and position. Based on their location and neighborhood relationship, areas hOc3d and hOc4d are putative anatomical substrates of functionally defined areas V3d and V3a, a hypothesis that can now be tested by comparing probabilistic cytoarchitectonic maps and activation studies of the living human brain.
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