Cytoarchitectonical analysis and probabilistic mapping of two extrastriate areas of the human posterior fusiform gyrus.
Cytoarchitectonical analysis and probabilistic mapping of two extrastriate areas of the human posterior fusiform gyrus.
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DOI：
10.1007/s00429-012-0411-8
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发表时间：
2013-03
影响因子：
3.1
通讯作者：
Amunts, Katrin
中科院分区：
文献类型：
--
作者：
Caspers, Julian;Zilles, Karl;Eickhoff, Simon B.;Schleicher, Axel;Mohlberg, Hartmut;Amunts, Katrin
关键词：
人类纹外视皮层包括许多功能明确的区域，这些区域在广泛使用的Brodmann细胞结构图中没有被识别。纹外皮层的腹侧部分特别致力于识别视觉对象，面孔和单词形式。我们分析了连续切片（20 μm）和细胞体染色的人脑中紧邻hOc 4v前外侧的区域，使用定量的非依赖性细胞结构方法进一步识别纹外皮质的解剖组织。两个新的cytoarchitectonical区域，FG 1和FG 2，被确定后梭状回。然后将10个死后大脑的结果与其MRI体积（在组织学处理之前获得）进行配准，进行3D重建，并在空间上归一化为蒙特利尔神经学研究所参考大脑。最后，概率地图生成的每个cytoarchitectonical区域的叠加在参考空间中的各个大脑的区域。与最近的功能成像研究的比较表明，这两个领域都位于对象相关的视觉皮层。FG 1填充视网膜定位映射区域VO-1和后梭形面部斑块之间的差距。FG 2可能是这个面部斑块的相关物。
The human extrastriate visual cortex comprises numerous functionally defined areas, which are not identified in the widely used cytoarchitectonical map of Brodmann. The ventral part of the extrastriate cortex is particularly devoted to the identification of visual objects, faces and word forms. We analyzed the region immediately antero-lateral to hOc4v in serially sectioned (20 μm) and cell body-stained human brains using a quantitative observer-independent cytoarchitectonical approach to further identify the anatomical organization of the extrastriate cortex. Two novel cytoarchitectonical areas, FG1 and FG2, were identified on the posterior fusiform gyrus. The results of ten postmortem brains were then registered to their MRI volumes (acquired before histological processing), 3D reconstructed, and spatially normalized to the Montreal Neurological Institute reference brain. Finally, probabilistic maps were generated for each cytoarchitectonical area by superimposing the areas of the individual brains in the reference space. Comparison with recent functional imaging studies yielded that both areas are located within the object-related visual cortex. FG1 fills the gap between the retinotopically mapped area VO-1 and a posterior fusiform face patch. FG2 is probably the correlate of this face patch.
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