Ultra-fast sequence clustering from similarity networks with SiLiX.
Ultra-fast sequence clustering from similarity networks with SiLiX.
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DOI:
10.1186/1471-2105-12-116
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发表时间:
2011-04-22
影响因子:
3
通讯作者:
Duret L
中科院分区:
文献类型:
--
作者:
Miele V;Penel S;Duret L
The number of gene sequences that are available for comparative genomics approaches is increasing extremely quickly. A current challenge is to be able to handle this huge amount of sequences in order to build families of homologous sequences in a reasonable time. We present the software package SiLiX that implements a novel method which reconsiders single linkage clustering with a graph theoretical approach. A parallel version of the algorithms is also presented. As a demonstration of the ability of our software, we clustered more than 3 millions sequences from about 2 billion BLAST hits in 7 minutes, with a high clustering quality, both in terms of sensitivity and specificity. Comparing state-of-the-art software, SiLiX presents the best up-to-date capabilities to face the problem of clustering large collections of sequences. SiLiX is freely available at http://lbbe.univ-lyon1.fr/SiLiX.
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