Parallel evolution of senescence in annual fishes in response to extrinsic mortality.
Parallel evolution of senescence in annual fishes in response to extrinsic mortality.
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DOI：
10.1186/1471-2148-13-77
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发表时间：
2013-04-03
影响因子：
3.4
通讯作者：
Cellerino A
中科院分区：
文献类型：
--
作者：
Tozzini ET;Dorn A;Ng'oma E;Polačik M;Blažek R;Reichwald K;Petzold A;Watters B;Reichard M;Cellerino A
早期的衰老进化理论预测，外在死亡率低的人群会延迟衰老。在脊椎动物中对这一理论的实验支持很少，部分原因是难以量化外在死亡率及其条件和密度依赖性成分，当考虑到这些成分时，可能会导致预测与“经典”理论的预测明显不同。在这里，我们研究了一年生的无鳃鱼属鱼类，其最长寿命取决于它们栖息的水体的持续时间。不同的一年生鱼类种群在其整个生命周期中不会经历不同强度的外在死亡率，但会受到栖息地突然终止的不同时间（和可预测性）的影响。在这方面，我们的研究可以测试当人群的生存前景不同时，衰老在自然环境中如何演变，但条件依赖性生存的影响有限。我们使用季节性池中持续时间不同的 10 个无鳃鱼种群来测试该参数如何影响这些一年生鱼类的两个独立分支的寿命和衰老。我们发现，来自干燥地区的复制种群的圈养寿命明显短于来自潮湿地区的种群。较短的寿命与两个进化枝中脂褐素（一种既定的年龄标记）的加速积累相关。对野生个体的分析证实，来自干燥栖息地的鱼类在自然条件下也能更快地积累脂褐质。这表明寿命较短的人群的生理恶化速度更快。我们的数据提供了一个强有力的定量例子，说明外在死亡率如何影响脊椎动物进化枝的衰老进化。 Nothobranchius 正在成为基因组模型物种。具有不同寿命的密切相关物种对的表征应该为识别导致自然种群衰老进化的遗传变异提供强大的范例。
Early evolutionary theories of aging predict that populations which experience low extrinsic mortality evolve a retarded onset of senescence. Experimental support for this theory in vertebrates is scarce, in part for the difficulty of quantifying extrinsic mortality and its condition- and density-dependent components that –when considered- can lead to predictions markedly different to those of the “classical” theories. Here, we study annual fish of the genus Nothobranchius whose maximum lifespan is dictated by the duration of the water bodies they inhabit. Different populations of annual fish do not experience different strengths of extrinsic mortality throughout their life span, but are subject to differential timing (and predictability) of a sudden habitat cessation. In this respect, our study allows testing how aging evolves in natural environments when populations vary in the prospect of survival, but condition-dependent survival has a limited effect. We use 10 Nothobranchius populations from seasonal pools that differ in their duration to test how this parameter affects longevity and aging in two independent clades of these annual fishes. We found that replicated populations from a dry region showed markedly shorter captive lifespan than populations from a humid region. Shorter lifespan correlated with accelerated accumulation of lipofuscin (an established age marker) in both clades. Analysis of wild individuals confirmed that fish from drier habitats accumulate lipofuscin faster also under natural conditions. This indicates faster physiological deterioration in shorter-lived populations. Our data provide a strong quantitative example of how extrinsic mortality can shape evolution of senescence in a vertebrate clade. Nothobranchius is emerging as a genomic model species. The characterization of pairs of closely related species with different longevities should provide a powerful paradigm for the identification of genetic variations responsible for evolution of senescence in natural populations.
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影响因子：
2
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
影响因子：
1.9
作者：
ABRAMS, PA
通讯作者：
ABRAMS, PA
影响因子：
7.8
作者：
Hsu, Chin-Yuan;Chiu, Ya-Chi
通讯作者：
Chiu, Ya-Chi
影响因子：
4.5
作者：
Kishi S;Bayliss PE;Uchiyama J;Koshimizu E;Qi J;Nanjappa P;Imamura S;Islam A;Neuberg D;Amsterdam A;Roberts TM
通讯作者：
Roberts TM
影响因子：
3.7
作者：
Ding, Lingling;Kuhne, Wendy W.;Dynan, William S.
通讯作者：
Dynan, William S.