Injectable polymerized high internal phase emulsions with rapid in situ curing.
Injectable polymerized high internal phase emulsions with rapid in situ curing.
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DOI：
10.1021/bm500754r
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发表时间：
2014-08-11
影响因子：
6.2
通讯作者：
Cosgriff-Hernandez, Elizabeth
中科院分区：
文献类型：
--
作者：
Moglia, Robert S.;Whitely, Michael;Dhavalikar, Prachi;Robinson, Jennifer;Pearce, Hannah;Brooks, Megan;Stuebben, Melissa;Cordner, Nicole;Cosgriff-Hernandez, Elizabeth
聚合高内相乳剂（polyHIPEs）已被用于制造可注射支架，用于原位修复不规则骨缺损并潜在地改善组织愈合。以前，热启动支架需要数小时才能治愈，这降低了临床转化的潜力。在这里，双筒注射器系统用于制造氧化还原引发的polyHIPEs，在注射时显著缩短固化时间，展示了三个甲基丙烯酸基大分子。研究了聚合聚乙烯固化时间、压缩性能和孔隙结构对氧化还原引发剂化学性质和浓度的影响。氧化还原引发剂浓度的增加将固化时间从几小时缩短到几分钟，并在不影响孔隙结构的情况下提高了压缩模量和强度。此外，未经固化的乳液在低温下储存6个月，对接枝性能的影响最小。这些研究表明，未固化的乳剂可以储存在临床，直到需要时再注射到刚性、高孔隙率的支架中快速固化。总之，我们已经改进了现有的可注射polyHIPE移植物的方法，以满足长储存时间和快速固化（<15分钟）的平移设计目标，而不牺牲孔隙度或机械性能。
Polymerized high internal phase emulsions (polyHIPEs) have been utilized in the creation of injectable scaffolds that cure in situ to fill irregular bone defects and potentially improve tissue healing. Previously, thermally initiated scaffolds required hours to cure, which diminished the potential for clinical translation. Here, a double-barrel syringe system for fabricating redox-initiated polyHIPEs with dramatically shortened cure times upon injection was demonstrated with three methacrylated macromers. The polyHIPE cure time, compressive properties, and pore architecture were investigated with respect to redox initiator chemistry and concentration. Increased concentrations of redox initiators reduced cure times from hours to minutes and increased the compressive modulus and strength without compromising the pore architecture. Additionally, storage of the uncured emulsion at reduced temperatures for 6 months was shown to have minimal effects on the resulting graft properties. These studies indicate that the uncured emulsions can be stored in the clinic until they are needed and then rapidly cured after injection to rigid, high-porosity scaffolds. In summary, we have improved upon current methods of generating injectable polyHIPE grafts to meet translational design goals of long storage times and rapid curing (<15 min) without sacrificing porosity or mechanical properties.
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影响因子：
5.5
作者：
Barbetta, A;Cameron, NR
通讯作者：
Cameron, NR
影响因子：
6.2
作者：
Christenson, Elizabeth M.;Soofi, Wafa;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
14
作者：
Temenoff, JS;Mikos, AG
通讯作者：
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影响因子：
2.4
作者：
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Weitz, DA
影响因子：
120.7
作者：
Munin, MC;Rudy, TE;Rubash, HE
通讯作者：
Rubash, HE