Neuronal reprogramming in treating spinal cord injury.
Neuronal reprogramming in treating spinal cord injury.
复制标题
在治疗脊髓损伤方面的神经元重编程。
DOI：
10.4103/1673-5374.330590
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发表时间：
2022-07
影响因子：
6.1
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Chen X;Li H
脊髓损伤是一种破坏性的中枢神经系统损伤，可能会损害患者的活动性和感觉功能。脊髓损伤的标志包括神经炎症、轴突变性、神经元丢失和反应性神经胶质增生。此外，在损伤部位形成胶质瘢痕为潜在的神经再生提供了抑制环境。除了轴突再生，治疗脊髓损伤的一个重要挑战是补充病理过程中丢失的神经元。然而，尽管数十年的研究努力，目前的策略，包括干细胞移植，并没有导致成功的临床治疗。此外，干细胞移植面临严重的障碍，如移植细胞的免疫排斥和伦理问题。体内神经元重编程是近年来发展起来的一项技术，是再生医学领域的一项重大突破。这项创新技术将内源性胶质细胞转化为功能性神经元，用于中枢神经系统的损伤修复。体内神经元重编程的可行性已经在包括脊髓损伤在内的不同神经系统疾病的模型中被许多实验室成功地证明。一些重编程因子，主要是前神经转录因子，已被用于将内源性胶质细胞重编程为具有不同表型的功能性神经元。到目前为止，在脊髓损伤模型中进行体内神经元重编程的文献仍然很少。在这篇综述中，我们总结了有限数量的这样的报告，并讨论了几个问题，我们认为是重要的应用在脊髓损伤以及其他中枢神经系统疾病的研究领域在体内神经元重编程。
Spinal cord injury represents a devastating central nervous system injury that could impair the mobility and sensory function of afflicted patients. The hallmarks of spinal cord injury include neuroinflammation, axonal degeneration, neuronal loss, and reactive gliosis. Furthermore, the formation of a glial scar at the injury site elicits an inhibitory environment for potential neuroregeneration. Besides axonal regeneration, a significant challenge in treating spinal cord injury is to replenish the neurons lost during the pathological process. However, despite decades of research efforts, current strategies including stem cell transplantation have not resulted in a successful clinical therapy. Furthermore, stem cell transplantation faces serious hurdles such as immunorejection of the transplanted cells and ethical issues. In vivo neuronal reprogramming is a recently developed technology and leading a major breakthrough in regenerative medicine. This innovative technology converts endogenous glial cells into functional neurons for injury repair in the central nervous system. The feasibility of in vivo neuronal reprogramming has been demonstrated successfully in models of different neurological disorders including spinal cord injury by numerous laboratories. Several reprogramming factors, mainly the pro-neural transcription factors, have been utilized to reprogram endogenous glial cells into functional neurons with distinct phenotypes. So far, the literature on in vivo neuronal reprogramming in the model of spinal cord injury is still small. In this review, we summarize a limited number of such reports and discuss several questions that we think are important for applying in vivo neuronal reprogramming in the research field of spinal cord injury as well as other central nervous system disorders.
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影响因子：
9.8
作者：
Heinrich C;Blum R;Gascón S;Masserdotti G;Tripathi P;Sánchez R;Tiedt S;Schroeder T;Götz M;Berninger B
通讯作者：
Berninger B
影响因子：
16.2
作者：
Burda JE;Sofroniew MV
通讯作者：
Sofroniew MV
影响因子：
23.9
作者：
Gascon, Sergio;Murenu, Elisa;Goetz, Magdalena
通讯作者：
Goetz, Magdalena
DOI：
10.1073/pnas.0511041103
发表时间：
2006-02-14
影响因子：
11.1
作者：
Conaco, C;Otto, S;Mandel, G
通讯作者：
Mandel, G
影响因子：
56.9
作者：
Goritz, Christian;Dias, David O.;Frisen, Jonas
通讯作者：
Frisen, Jonas