Decreased hippocampal volume in healthy girls at risk of depression.
Decreased hippocampal volume in healthy girls at risk of depression.
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DOI：
10.1001/archgenpsychiatry.2009.202
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发表时间：
2010-03
影响因子：
--
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Chen MC;Hamilton JP;Gotlib IH
研究人员已经证明，抑郁症患者的海马体比非抑郁症患者的小。然而，抑郁症海马体积减少的时间或因果关系尚不清楚。为了验证海马体积减少先于抑郁症发作的假设，因此可能与抑郁症的发作有关，我们使用磁共振成像检查了抑郁症家族风险高和低的个体的大脑结构体积。使用全脑基于体素的形态测量和双侧海马的手动追踪来分析来自磁共振成像的解剖图像。一所研究型大学55名年龄在9岁至15岁之间的女孩：23名女儿的母亲在女儿的一生中反复发作抑郁症（高风险），32名年龄匹配的女儿的母亲没有精神病理学史（低风险）。没有一个女孩有任何过去或现在的轴-1精神病理学。基于体素的形态测量学脑物质密度估计和追踪海马体积的组间差异。基于体素的形态测量学分析表明，抑郁症高危个体双侧海马区簇状灰质密度显著低于低危个体（p<0.001）。追踪显示高风险参与者左侧海马体积减少（p<0.05）。与抑郁症发生的低家族风险个体相比，高风险个体的海马体积减小，表明与抑郁症相关的神经解剖学异常可能先于抑郁症发作，并影响这种疾病的发展和进程。
Researchers have documented that the hippocampus is smaller in depressed than in nondepressed individuals. The temporal or causal association of this reduction in hippocampal volume in depression, however, is not known. To test the hypothesis that reduced hippocampal volume precedes and, therefore, may be implicated in the onset of, depression, we used magnetic resonance imaging to examine brain structure volume in individuals at high and low familial risk for depression. Anatomical images from magnetic resonance imaging were analyzed using both whole-brain voxel-based morphometry and manual tracing of bilateral hippocampus. A research university. 55 girls between the ages 9 and 15: 23 daughters of mothers with recurrent episodes of depression in the daughter’s lifetime (high-risk) and 32 age-matched daughters of mothers with no history of psychopathology (low-risk). None of the girls had any past or current Axis-1 psychopathology. Group differences in voxel-based morphometry brain matter density estimates and traced hippocampal volume. Voxel-based morphometry analyses indicated that individuals at high risk for depression had significantly less gray matter density in clusters in bilateral hippocampus (p<0.001) than did low-risk participants. Tracing yielded a volumetric reduction in the left hippocampus in the high-risk participants (p<0.05). Compared with individuals at low familial risk for the development of depression, high-risk individuals have reduced hippocampal volume, indicating that neuroanatomical anomalies associated with depression may precede the onset of a depressive episode and influence the development and course of this disorder.
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影响因子：
5.7
作者：
Hayasaka, S;Phan, KL;Nichols, TE
通讯作者：
Nichols, TE
影响因子：
5.7
作者：
Bergouignan, Loretxu;Chupin, Marie;Fossati, Philippe
通讯作者：
Fossati, Philippe
影响因子：
25
作者：
Gilbertson, MW;Shenton, ME;Pitman, RK
通讯作者：
Pitman, RK
影响因子：
5.7
作者：
Good, CD;Johnsrude, IS;Frackowiak, RSJ
通讯作者：
Frackowiak, RSJ
DOI：
10.1073/pnas.211427898
发表时间：
2001-10-23
影响因子：
11.1
作者：
Czéh, B;Michaelis, T;Fuchs, E
通讯作者：
Fuchs, E