Blood type and the microbiome- untangling a complex relationship with lessons from pathogens.

Blood type and the microbiome- untangling a complex relationship with lessons from pathogens.
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DOI:
10.1016/j.mib.2020.06.008
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发表时间:
2020-08
影响因子:
5.4
通讯作者:
Lozupone, Catherine A.
Lozupone, Catherine A.
中科院分区:
生物学2区
文献类型:
--
作者:
Arnolds, Kathleen L.;Martin, Casey G.;Lozupone, Catherine A.

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构成人类微生物群落的复杂微生物群落受到宿主和环境因素的影响。在这里,我们讨论人类生物学的一个基本方面--血型--如何有助于塑造这个微观生态系统。尽管这个问题在很大程度上仍未被探索,但我们从数十年来描述病原体和血型之间关系的工作中收集了见解。塑造这些关系的细菌策略、分子机制和宿主反应可能与描述血型和共生体相互作用的特征相似。了解这些细微差别的相互作用将扩大我们分析和操纵人类微生物组的能力。
The complex communities of microbes that constitute the human microbiome are influenced by host and environmental factors. Here we address how a fundamental aspect of human biology, blood type, contributes to shaping this microscopic ecosystem. Although this question remains largely unexplored, we glean insights from decades of work describing relationships between pathogens and blood type. The bacterial strategies, molecular mechanisms, and host responses that shaped those relationships may parallel those that characterize how blood type and commensals interact. Understanding these nuanced interactions will expand our capacity to analyze and manipulate the human microbiome.
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