The pial vasculature of the mouse develops according to a sensory-independent program.
The pial vasculature of the mouse develops according to a sensory-independent program.
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DOI：
10.1038/s41598-018-27910-3
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发表时间：
2018-06-29
影响因子：
4.6
通讯作者：
Drew PJ
中科院分区：
文献类型：
--
作者：
Adams MD;Winder AT;Blinder P;Drew PJ
脑血管系统的组织是为了满足大脑的代谢需要。产后早期的感觉剥夺导致神经活动改变和代谢需求降低。神经活动对血管发育的某些方面具有指导作用，剥夺导致被剥夺脑区的毛细血管密度变化。然而，目前尚不清楚枕小动脉网络是否也受到感觉剥夺的影响，枕小动脉网络包含许多小脑膜吻合（lma），使网络具有抗闭塞的冗余性。我们量化了早期拔须对小鼠主要感觉区（触须皮质、前肢/后肢皮质、视觉皮质和听觉皮质）lma和穿透性小动脉（PAs）密度的影响。我们发现穿透性小动脉的密度在皮质区域是相同的，尽管后肢的lma密度高于其他感觉区域。我们发现pa和lma的密度以及网络拓扑的定量测量不受感觉剥夺的影响。我们的研究结果表明，出生后枕动脉网络的发育对感觉剥夺是稳健的。
The cerebral vasculature is organized to supply the brain’s metabolic needs. Sensory deprivation during the early postnatal period causes altered neural activity and lower metabolic demand. Neural activity is instructional for some aspects of vascular development, and deprivation causes changes in capillary density in the deprived brain region. However, it is not known if the pial arteriole network, which contains many leptomeningeal anastomoses (LMAs) that endow the network with redundancy against occlusions, is also affected by sensory deprivation. We quantified the effects of early-life sensory deprivation via whisker plucking on the densities of LMAs and penetrating arterioles (PAs) in anatomically-identified primary sensory regions (vibrissae cortex, forelimb/hindlimb cortex, visual cortex and auditory cortex) in mice. We found that the densities of penetrating arterioles were the same across cortical regions, though the hindlimb representation had a higher density of LMAs than other sensory regions. We found that the densities of PAs and LMAs, as well as quantitative measures of network topology, were not affected by sensory deprivation. Our results show that the postnatal development of the pial arterial network is robust to sensory deprivation.
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